Results 41 to 50 of about 24,118,381 (294)

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

FONDUE—Fine-Tuned Optimization: Nurturing Data Usability & Efficiency

Journal of Big Data
To provide good results and decisions in data-driven systems, data quality must be ensured as a primary consideration. An important aspect of this is data cleaning.
Valerie Restat, Indra Diestelkämper, Meike Klettke, Uta Störl   +3 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Editorial - 7th International Students Summer School on Human Growth - Data Analysis and Statistics

Human Biology and Public Health
Statistics is the key skill required by reseachers to answer scientific questions based on often complex data sets. 9 students and young researchers from Indonesia, South Africa, Spain, Slovakia, and Germany were educated and trained on their own data ...
Detlef Groth, Michael Hermanussen, Christiane Scheffler   +2 more
doaj   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Data Quality Improvement Method for Power Equipment Condition Based on Stacked Denoising Autoencoders Improved by Particle Swarm Optimization

Shanghai Jiaotong Daxue xuebao
Big data related to power equipment condition is experiencing explosive growth. However, equipment failures and personnel errors result in dirty data, having a negative effect on data quality and subsequent analysis results.
JI Rong, HOU Huijuan, SHENG Gehao, ZHANG Lijing, SHU Bo, JIANG Xiuchen
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Supporting Predictive Maintenance of a Ship by Analysis of Onboard Measurements

Journal of Marine Science and Engineering, 2022
Ship hull and propeller fouling has a severe impact both on fuel costs and on greenhouse gas emission, thus, it is an important subject to consider when developing a maintenance plan to enhance energy efficiency and reduce gas emissions from ships.
Shukui Liu, Haoliang Chen, Baoguo Shang, Apostolos Papanikolaou   +3 more
doaj   +1 more source

Semandaq: a data quality system based on conditional functional dependencies [PDF]

, 2008
We present SEMANDAQ, a prototype system for improving the quality of relational data. Based on the recently proposed conditional functional dependencies (CFDs), it detects and repairs errors and inconsistencies that emerge as violations of these ...
Fan, Wenfei; id_orcid, Geerts, Floris, Jia, Xibei   +2 more
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