IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley +1 more source
Hands-on training about data clustering with orange data mining toolbox. [PDF]
Demšar J, Zupan B.
europepmc +1 more source
Characterization of the key membrane protein cytochrome Cyc2 from Ghiorsea bivora
This study reports the first detailed biochemical analysis of Cyc2TAG1_1, a cytochrome protein involved in microbial iron oxidation. We produced and purified this enzyme in E. coli, then measured its iron‐oxidizing efficiency, and characterized its electrical and structural properties.
Josiane Azizi +6 more
wiley +1 more source
PLNMFG: Pseudo-label guided non-negative matrix factorization model with graph constraint for single-cell multi-omics data clustering. [PDF]
Yuan H, Liu M, Qiu Y, Ching WK, Zou Q.
europepmc +1 more source
Subspace clustering for complex data.
The increasing potential of storage technologies and information systems has opened the possibility to conveniently and affordably gather large amounts of complex data. Going beyond simple descriptions of objects by some few characteristics, such data sources range from high dimensional vector spaces over imperfect data containing errors to network ...
openaire +3 more sources
Student engagement extends beyond simple attendance. Across 891 bioscience students from three universities, attendance behaviour was associated mainly with structural influences, whereas classroom spatial behaviour reflected affective and sensory factors.
Nigel Page +4 more
wiley +1 more source
Author Correction: Learning model combined with data clustering and dimensionality reduction for short-term electricity load forecasting. [PDF]
Bae HJ, Park JS, Choi JH, Kwon HY.
europepmc +1 more source
A rapid visual test combines DNA amplification, CRISPR–based target verification, and a lateral flow strip to detect Streptococcus suis. The assay gives results in about 45 min, reduces false‐positive interpretation, and does not require fluorescence equipment.
Liu‐xin Li +7 more
wiley +1 more source
Learning model combined with data clustering and dimensionality reduction for short-term electricity load forecasting. [PDF]
Bae HJ, Park JS, Choi JH, Kwon HY.
europepmc +1 more source
A nationwide student survey on biochemistry learning resources in Italy
We conducted a survey among Italian university students to investigate their preferred study materials for biochemistry. We then analyzed the collected data to identify these materials. This information may be valuable to the Biochemistry educational community. The graphical abstract was created with Claude (Opus 5.5; Anthropic, 2026).
Anna Marabotti +4 more
wiley +1 more source

