A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He +8 more
wiley +1 more source
Efficient data collection for establishing practical identifiability via active learning. [PDF]
Liu X, Wanika L, Chappell MJ, Branke J.
europepmc +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Identifying Gaps in Mobile Data Collection by Frontline Health Workers in Bangladesh. [PDF]
Patwary MM, Islam N.
europepmc +1 more source
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
An unexpected gills roommate from museum collections: description of a new species of Microcotyle Van Beneden & Hesse, 1863 (Mazocraeidea: Microcotylidae) from the ballan wrasse Labrus bergylta Ascanius (Teleostei, Labridae) off Sweden with novel data for Microcotyle donovani Van Beneden & Hesse, 1863 [PDF]
Chahinez Bouguerche
openalex +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
MQTT-Based Architecture for Real-Time Data Collection and Anomaly Detection in Smart Livestock Housing. [PDF]
Ko KI, Lee MH.
europepmc +1 more source

