Results 161 to 170 of about 3,772,561 (311)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Advanced mathematical modeling and simulation of high altitude balloons for precision stratospheric data collection. [PDF]

Sci Rep
Slimene MB, Khlifi MA, Tlili I.
europepmc   +1 more source

Data Collection User Instructions

, 2022
Bree Norlander, Michelle Fellows, Chris Jowaisas, Joel Sam, Stanley Boakye-Achampong, Jason Young   +5 more
openalex   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

NOURICITY - Technical Report on Qualitative Data Collection (Focus Group Discussions)

, 2020
Andrea Fongar, Beatrice Ekesa, Y. Dijkxhoorn, Vincent Linderhof   +3 more
openalex   +1 more source

New Bruker Nonius' integrated data collection and processing environment [PDF]

, 2002
Joerg Kaercher, Rob Hooft, Ross Lancaster, Sepriana Leo, Andrew Leonard, Michael Ruf   +5 more
openalex   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

A national study of substance use: Demonstrated use of recommendations for best practice online data collection. [PDF]

PLoS One
Bontemps AP, Pridgen BE, Wagner WP, Cropsey KL.   +3 more
europepmc   +1 more source

DATA COLLECTION SCHEMES FOR URBAN MONITORING LAND OF POPULATION

, 2020
Vladyslav Smilka
openalex   +2 more sources

Pilot project on the implementation of SSD2 in the frame of the electronic transmission of harmonised data collection of analytical results to EFSA: Denmark [PDF]

, 2017
Jens Hinge Andersen, Louise Grønhøj Hørbye Jensen, Mikael Pedersen, Pernille Bjørn Petersen   +3 more
openalex   +1 more source