Results 331 to 340 of about 31,546,768 (400)

Possible role of human ribonuclease dicer in the regulation of R loops

FEBS Open Bio, EarlyView.
R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik, Paulina Krzeminska, Anna Kurzynska‐Kokorniak   +2 more
wiley   +1 more source

"It's very important that you measure throughout that journey…": patient perspectives towards quality-of-life data collection following haematopoietic cell transplant. [PDF]

BMC Cancer
Pugh G, Young L, Yiallouridou C, Hart D, Dean K, Danby R.   +5 more
europepmc   +1 more source

Soman induces endoplasmic reticulum stress and apoptosis of cerebral organoids via the GRP78‐ATF6‐CHOP signaling pathway

FEBS Open Bio, EarlyView.
Cerebral organoids were employed as a novel model to explore the neurotoxicity of soman. Soman inhibited acetylcholinesterase activity, increased cell apoptosis and upregulated endoplasmic reticulum (ER) stress markers glucose‐regulated protein 78 (GRP78), activating transcription factor 6 (ATF6) and C/EBP homologous protein (CHOP).
Yue Wei, Zhanbiao Liu, Jingjing Shi, Qian Jin, Wenqian Chen, Xuejun Chen, Liqin Li, Hui Chen   +7 more
wiley   +1 more source

SEMbeddings: how to evaluate model misfit before data collection using large-language models. [PDF]

Front Psychol
Feraco T, Toffalini E.
europepmc   +1 more source

Downregulation of O‐GlcNAcylation enhances etoposide‐induced p53‐mediated apoptosis in HepG2 human liver cancer cells

FEBS Open Bio, EarlyView.
Etoposide, a topoisomerase II inhibitor, reduces O‐GlcNAcylation in HepG2 liver cancer cells. Further inhibition of O‐GlcNAc transferase by OSMI‐1 enhanced etoposide‐induced apoptosis, lowering the IC50 for viability and increasing the EC50 for cytotoxicity.
Jaehoon Lee, Gi‐Bang Koo, Jihye Park, Byung‐Cheol Han, Mijin Kwon, Seung‐Ho Lee   +5 more
wiley   +1 more source

Narrative Review of the Validity and Cross-Context Equivalence of Healthy Diet Metrics and Their Data Collection Methods for Global Monitoring. [PDF]

Curr Dev Nutr
Sattamini IF, Hanley-Cook GT, Frongillo EA, Coates J, Healthy Diets Monitoring Initiative.   +4 more
europepmc   +1 more source

On subcellular distribution of the zinc finger 469 protein (ZNF469) and observed discrepancy in the localization of endogenous and overexpressed ZNF469

FEBS Open Bio, EarlyView.
ZNF469 regulates the expression of genes encoding extracellular matrix proteins. Endogenous ZNF469 is predominantly cytoplasmic, while in transfected cells, it forms aggregates reminiscent of biomolecular condensates, located mainly in the nucleus. These condensates exhibit overlapping staining with proteasomes and are also associated with the mitotic ...
Anne Elisabeth Christensen Mellgren, Ileana Cristea, Thomas Stevenson, Endy Spriet, Per Morten Knappskog, Stig Ove Bøe, Harald Kranz, Sushma N. Grellscheid, Eyvind Rødahl   +8 more
wiley   +1 more source

Streamlining Acute Stroke Processes and Data Collection: A Narrative Review. [PDF]

Healthcare (Basel)
Forward A, Sahli A, Kamal N.
europepmc   +1 more source

Barriers and facilitators to caregiver comfort with health-related social needs data collection in the pediatric clinical setting. [PDF]

Health Serv Res
Brown R, Barouk N, McPeak K, Fein J, Cullen D.   +4 more
europepmc   +1 more source

Real ethics has dirty feet - data collector perspectives on risk exposure during data collection in conflict-affected Eastern DRC. [PDF]

Confl Health
Jansen S, Niyonsenga J, Nsabimana E, Kagaba M, Rutembesa E, Slegh H, Mihigo B, Mutabaruka J.   +7 more
europepmc   +1 more source