Results 191 to 200 of about 51,655,942 (350)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
A study on the correlation between types and duration of moderate-to-vigorous physical activity and mobile phone dependence among adolescents. [PDF]
Front Public HealthYang M.
europepmc +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Shared genetic architecture of smoking dependence and Crohn's disease: A cross-trait analysis of GWAS summary statistics. [PDF]
Tob Induc DisJi A, Xu W, Xiong H, Zhong H, Zeng C.
europepmc +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Nicotine Dependence and Risk of Postpartum Psychosis: A Large Real-World Cohort Study. [PDF]
CureusKuo J, Le KD, Gomez K, Jiang X.
europepmc +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
An EScheduler-Based Data Dependence Analysis and Task Scheduling for Parallel Circuit Simulation
IEEE Transactions on Circuits and Systems - II - Express Briefs, 2011 Xiaoming Chen +4 more
semanticscholar +1 more source
The serial mediating roles of AI self-efficacy and academic procrastination in the association between AI literacy and AI dependence among Chinese undergraduates. [PDF]
Aust J PsycholWu H, Ni H, He J, Wee EH.
europepmc +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source