Results 51 to 60 of about 3,462,120 (290)

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács   +8 more
wiley   +1 more source

Data dependence [PDF]

open access: yes
A speech at the Middle Tennessee State University, Annual Economic Outlook Conference, Murfreesboro, Tenn., Sept.
William Poole
core   +3 more sources

Iterative functional-differential system with retarded argument

open access: yesJournal of Numerical Analysis and Approximation Theory, 2006
Existence, uniqueness and data dependence results of solution to the Cauchy problem for iterative functional-differential system with delays are obtained using weakly Picard operator theory.
Diana Otrocol
doaj   +2 more sources

Conventional versus network dependence panel data gravity model specifications [PDF]

open access: yes, 2019
Past focus in the panel gravity literature has been on multidimensional fixed effects specifications in an effort to accommodate heterogeneity. After introducing conventional multidimensional fixed effects, we find evidence of cross-sectional dependence
Fischer, Manfred M., LeSage, James P.
core  

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson   +3 more
wiley   +1 more source

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski   +9 more
wiley   +1 more source

Outcomes of Live Virus Vaccination in Patients With Vascular Anomalies Being Treated With Sirolimus

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Live vaccination in patients with vascular anomalies (VA) receiving sirolimus remains controversial due to immunosuppressive effects and theoretical risks. Procedure This single‐center retrospective study included patients with VA less than 4 years old at the start of sirolimus therapy who were incompletely vaccinated.
Svatava Merkle   +5 more
wiley   +1 more source

Dependence of the Index of Biologically Active Ultraviolet Radiation on the Season and Time of Day

open access: yesAtmosphere, 2022
In the present work, the data from the monitoring of the biologically active ultraviolet (UV) radiation of the Sun at the National Institute of Geophysics, Geodesy and Geography, Bulgarian Academy of Sciences for the period 2007–2021 were used.
Rumiana Bojilova   +2 more
doaj   +1 more source

The implications of final L3 measurement of $\sigma_{tot}(\gamma\gamma\to b\bar{b}

open access: yes, 2006
he excess of data on the total cross section of $\bar{b}b$ production in $\gamma\gamma$ collisions over QCD predictions, observed by L3, OPAL and DELPHI Collaborations at LEP2, has so far defied explanation.
Chyla, Jiri
core   +1 more source

Pulmonary Dysfunction Is Associated With Sleep Study Abnormalities in Children With Sickle Cell Disease: A Multicenter Study

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Pulmonary dysfunction and sleep abnormalities are common in children with sickle cell disease (SCD) and are associated with worse clinical outcomes. Whether spirometry abnormalities are associated with polysomnography (PSG) findings remains unclear.
Ammar Saadoon Alishlash   +4 more
wiley   +1 more source

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