Results 141 to 150 of about 28,374,038 (313)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Search Engine for Open Geospatial Consortium Web Services Improving Discoverability through Natural Language Processing-Based Processing and Ranking

ISPRS International Journal of Geo-Information
The improvement of search engines for geospatial data on the World Wide Web has been a subject of research, particularly concerning the challenges in discovering and utilizing geospatial web services.
Elia Ferrari, Friedrich Striewski, Fiona Tiefenbacher, Pia Bereuter, David Oesch, Pasquale Di Donato   +5 more
doaj   +1 more source

GENERATOR Breast DataMart-The Novel Breast Cancer Data Discovery System for Research and Monitoring: Preliminary Results and Future Perspectives. [PDF]

J Pers Med, 2021
Marazzi F, Tagliaferri L, Masiello V, Moschella F, Colloca GF, Corvari B, Sanchez AM, Capocchiano ND, Pastorino R, Iacomini C, Lenkowicz J, Masciocchi C, Patarnello S, Franceschini G, Gambacorta MA, Masetti R, Valentini V.   +16 more
europepmc   +1 more source

President's Message: Data Discovery

Information Technology and Libraries, 2011
President's Message: Data ...
openaire   +3 more sources

CESSDA Webinar: Data Discovery

, 2019
Slides from CESSDA Webinar on Data Discovery Data discovery is a crucial stage in the research process, especially in the social sciences and humanities as many valuable studies have originated from secondary data. Speakers from the Czech Social Science Data Archive (CSDA), Johana Chylíková and Martin Vávra, took participants on a tour through ...
Chylíková, Johana, Vávra, Martin, Bašná, Kristýna   +2 more
openaire   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Identifying metadata commonalities across restricted health data sources: A mixed methods study exploring how to improve the discovery of and access to restricted datasets

Journal of eScience Librarianship
Background: While open datasets are adopting FAIR principles to improve their discovery and use, restricted data—those only accessible via request or application—have fallen behind.
Ambery Leahey, Grant Gibson, Julie Shi, Kelly Stathis, Kevin B. Read, Lynn Peterson, Sarah Rutley, Victoria Smith   +7 more
doaj   +2 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Correction to: Privacy-protecting, reliable response data discovery using COVID-19 patient observations. [PDF]

J Am Med Inform Assoc, 2023
europepmc   +1 more source