Results 231 to 240 of about 1,446,153 (317)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

JuNkIE-CLImax: exploring multidimensional images in notebooks and the terminal. [PDF]

MicroPubl Biol
Fernandez-Gonzalez R, Hawkins R.
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Health Communication Campaign Performance During the HEALing Communities Study: Cross-Sectional Examination of Digital Advertising Methods. [PDF]

J Med Internet Res
Lewis N, Reynolds J, Krause D, Reeves PM, Luster J, Stein MD, Walsh SL, Farmer A, Lofwall MR, Roberts MF, Surratt HL, Crockett BN, Stephens K, Bursey K, Mattson K, Slater MD.   +15 more
europepmc   +1 more source

Correction to "Deep GIST: Deep Learning Models for Predicting the Distribution of Hydration Thermodynamics around Proteins". [PDF]

J Chem Inf Model
Fukushima Y, Yoshidome T.
europepmc   +1 more source