Results 171 to 180 of about 4,521,731 (325)

A NASTRAN model of a large flexible swing-wing bomber. Volume 5: NASTRAN model development-fairing structure [PDF]

The NASTRAN model plan for the fairing structure was expanded in detail to generate the NASTRAN model of this substructure. The grid point coordinates, element definitions, material properties, and sizing data for each element were specified. The fairing
Latham, R. A., Mock, W. D.
core   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

A Data Element-Function Conceptual Model for Data Quality Checks. [PDF]

EGEMS (Wash DC), 2019
Rogers JR, Callahan TJ, Kang T, Bauck A, Khare R, Brown JS, Kahn MG, Weng C.   +7 more
europepmc   +1 more source

Experimental data for development of finite element models: head/thoraco-abdomen/pelvis. Volume II - thoraco-abdomen. Final technical report [PDF]

, 1985
Guy S. Nusholtz
openalex  

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Elementary Data Quality Elements

, 2004
Data quality is obviously a good thing and an attractive goal to pursue. But what is data quality? The paper will give an overview of the literature on data quality and present the intuitive, the empirical and the ontological approaches that lead to a focus on dimensions or elements of data quality.
openaire   +2 more sources

Time, the final frontier

Molecular Oncology, EarlyView.
This article advocates integrating temporal dynamics into cancer research. Rather than relying on static snapshots, researchers should increasingly consider adopting dynamic methods—such as live imaging, temporal omics, and liquid biopsies—to track how tumors evolve over time.
Gautier Follain, Michal Dibus, Omkar Joshi, Guillaume Jacquemet   +3 more
wiley   +1 more source

CDEMapper: enhancing National Institutes of Health common data element use with large language models. [PDF]

J Am Med Inform Assoc
Wang Y, Huang J, He H, Zhang V, Zhou Y, Hao X, Ram P, Qian L, Xie Q, Weng RL, Lin F, Hu Y, Cui L, Jiang X, Xu H, Hong N.   +15 more
europepmc   +1 more source

Analyses of Inverse Boundary Value Problems with Noisy Data Using Alternating Boundary Element Inversion Scheme and Their Regularization

, 2000
Akira Furukawa, Shiro KUBO, Seiji Ioka
openalex   +2 more sources