Results 171 to 180 of about 4,882,254 (344)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

CDEMapper: enhancing National Institutes of Health common data element use with large language models. [PDF]

J Am Med Inform Assoc
Wang Y, Huang J, He H, Zhang V, Zhou Y, Hao X, Ram P, Qian L, Xie Q, Weng RL, Lin F, Hu Y, Cui L, Jiang X, Xu H, Hong N.   +15 more
europepmc   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Management of the essential data element in the differential diagnosis of oral medicine: An effective step in promoting oral health.

J Educ Health Promot, 2020
Ehtesham H, Safdari R, Mansourian A, Tahmasebian S, Mohammadzadeh N, Pourshahidi S.   +5 more
europepmc   +1 more source

Common data element

, 2019
Jay Gajera, Francis Deng
openaire   +1 more source

Data Element Concept [PDF]

, 2020
openaire   +1 more source

A novel, finite-element-based framework for sparse data solution reconstruction and multiple choices [PDF]

Wiera Bielajewa, Malcolm Baxter, Perumal Nithiarasu   +2 more
openalex   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Data element investment strategy: How can leaders and followers innovate in dynamic market environments. [PDF]

PLoS One
Fang Y, Wei W, Su R.
europepmc   +1 more source

Developing a data element repository to support EHR-driven phenotype algorithm authoring and execution. [PDF]

J Biomed Inform, 2016
Jiang G, Kiefer RC, Rasmussen LV, Solbrig HR, Mo H, Pacheco JA, Xu J, Montague E, Thompson WK, Denny JC, Chute CG, Pathak J.   +11 more
europepmc   +1 more source