Results 251 to 260 of about 4,521,731 (325)

Bayesian inference for data assimilation using Least-Squares Finite Element methods

, 2010
Richard P. Dwight
openalex   +2 more sources

Elements of a Data-Driven Approach to Adaptation

, 2016
Adaptation is what enables a system to respond to perturbations in its environment. Even though case-based reasoning is commonly thought of as a data-driven problem-solving paradigm, adaptation methods often follow a model-driven pattern. This paper discusses what a purely data-driven approach to adaptation might look like.
openaire   +1 more source

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias, Ana Oitabén, Sonia Zumalave, Bernardo Rodriguez‐Martin, María Gallardo‐Gómez, Martín Santamarina, Ana Pequeño‐Valtierra, Laura Juaneda‐Magdalena, Ramón García‐Escudero, José Luis López‐Cedrún, Máximo Fraga, José M. C. Tubio, Mónica Martínez‐Fernández   +12 more
wiley   +1 more source

First Insights into Bioaccumulation Patterns in Different Tissues of the Greenland Shark <i>Somniosus microcephalus</i> from Kulusuk (Southeastern Greenland). [PDF]

Biology (Basel)
Reinero FR, Sperone E, Gallo S, Barca D, Leonetti FL, Giglio G, Micarelli P.   +6 more
europepmc   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Study on the shear performance of GFRP perforated plate connectors. [PDF]

Sci Rep
Li Y, Xue D, Chu R, Zhang Y, Yuan Z.
europepmc   +1 more source

Clinical Data Element Ontology for Unified Indexing and Retrieval of Data Elements across Multiple Metadata Registries. [PDF]

Healthc Inform Res, 2014
Jeong S, Kim HH, Park YR, Kim JH.
europepmc   +1 more source

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source