Results 41 to 50 of about 4,364,912 (233)

A cellular system to study responses to a collision between the transcription complex and a protein‐bound nick in the DNA template

FEBS Letters, EarlyView.
We present the cellular transcription‐coupled Flp‐nick system allowing the introduction of a Top1‐mimicking cleavage complex (Flpcc) at a Flp recognition target site within a controllable LacZ gene. LacZ transcription leads to the collision of RNA polymerase II (RNAPII) with Flpcc, and this causes RNAPII stalling, ubiquitination, and degradation.
Petra Herring, Morten Roedgaard, Camilla Myrup Holst, Helene Christensen, Birgitta R. Knudsen, Lotte Bjergbaek, Anni Hangaard Andersen   +6 more
wiley   +1 more source

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

Cross Section Limits for the $^{208}$Pb($^{86}$Kr,n)$^{293}$118 Reaction

, 2002
In April-May, 2001, the previously reported experiment to synthesize element 118 using the $^{208}$Pb($^{86}$Kr,n)$^{293}$118 reaction was repeated. No events corresponding to the synthesis of element 118 were observed with a total beam dose of 2.6 x 10$^
Adamian, Adamian, Beckmann, Bender, Bender, C. M. Folden, Cherepanov, D. C. Hoffman, D. M. Lee, D. Peterson, Denisov, Denisov, Ghiorso, Giardina, Gregorich, Gupta, H. Nitsche, Hofmann, Hofmann, J. B. Patin, J. P. Omtvedt, K. Aleklett, K. E. Gregorich, Koura, Kruppa, L. A. Omtvedt, L. Stavsetra, Mamdouh, Meng, Morimoto, Muntian, Myers, Myers, Ninov, Ninov, Ninov, P. A. Wilk, P. M. Zielinski, R. Sudowe, Reinhard, Ren, Royer, Siwek-Wilczynska, Smolańczuk, Smolańczuk, Smolańczuk, Smolańczuk, Smolańczuk, Stodel, Swan, T. N. Ginter, W. Loveland, Ćwiok   +52 more
core   +3 more sources

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

New determination of $\mathcal{S} \mathcal{T} \langle N| \overline{q} D_{\mu} D_{\nu} q |N \rangle$ based on recent experimental constraints

, 2015
The symmetric and traceless part of the matrix element $\mathcal{S} \mathcal{T} \langle N| \overline{q} D_{\mu} D_{\nu} q |N \rangle$ can be determined from the second moment of the twist-3 parton distribution function $e(x)$.
Gubler, Philipp, Jeong, Kie Sang, Lee, Su Houng   +2 more
core   +1 more source

Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis

FEBS Letters, EarlyView.
Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner, Juthamas Khamseekaew, M. Gregor Madej, Linda Geiges, Bardha Azemi, Christine Ziegler, Christoph Korbmacher, Alexandr V. Ilyaskin   +7 more
wiley   +1 more source

A direct element resequencing procedure [PDF]

Element by element frontal solution algorithms are utilized in many of the existing finite element codes. The overall computational efficiency of this type of procedure is directly related to the element data input sequence. Thus, it is important to have
Akin, J. E., Fulford, R. E.
core   +1 more source

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Evidence for Miocene subduction beneath the Alboran Sea (Western Mediterranean) from 40Ar/39Ar age dating and the geochemistry of volcanic rocks from holes 977A and 978A [PDF]

, 1999
Volcanic pebbles in gravels from Sites 977 and 978 in the Alboran Sea (western Mediterranean) were dated (using the 40Ar/ 39Ar single-crystal laser technique) and analyzed for their major- and trace-element compositions (determined by X-ray ...
Duggen, Svend, Garbe-Schönberg, Dieter, Hoernle, Kaj, Mocek, Beate, van den Bogaard, Paul   +4 more
core  

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

FEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang, Frans Bianchi, Geert van den Bogaart   +2 more
wiley   +1 more source