Results 51 to 60 of about 4,521,731 (325)

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

FEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang, Frans Bianchi, Geert van den Bogaart   +2 more
wiley   +1 more source

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source

Comparative Study of Data Elements in Psychiatric History and Assessment Forms in Selected Countries

مجله انفورماتیک سلامت و زیست پزشکی, 2016
Introduction: Considering the importance of accurate documentation in psychiatric history and mental assessment and its effect on the current and future treatment among patients, this study aimed to determine data elements in the psychiatric history and ...
Amir Rezaei Ardani, Leila Ahmadian, khalil Kimiyafar, Faezeh Rohani, Zahra Ebnehoseini   +4 more
doaj  

The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by UDP‐glucuronic acid 4‐epimerase

FEBS Letters, EarlyView.
UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg, Laura De Cnop, Bernd Nidetzky   +2 more
wiley   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Investigation into authorized public data operation: its positioning and nature

大数据, 2023
At present, the theory and practice of authorized data operation are still chaotic and controversial.Based on the clarification of what open data means in the Chinese context, the current theory that authorized data operation is either complementary to ...
Feng GAO
doaj  

Mapping of Alzheimer’s disease related data elements and the NIH Common Data Elements

BMC Medical Informatics and Decision Making
Abstract Background Alzheimer’s Disease (AD) is a devastating disease that destroys memory and other cognitive functions. There has been an increasing research effort to prevent and treat AD. In the US, two major data sharing resources for AD research are the National Alzheimer’s Coordinating Center (NACC) and the ...
Xubing Hao, Rashmie Abeysinghe, Fengbo Zheng, Paul E. Schulz, The Alzheimer’s Disease Neuroimaging Initiative, Licong Cui   +5 more
openaire   +4 more sources

Advanced nonlinear modelling techniques for switched reluctance machines [PDF]

, 2003
This paper gives an overview of different modelling techniques to describe the nonlinear behaviour of both saturated switched reluctance machine (SRM) and power electronic converter.
Belmans, Ronnie, D'Hulster, Frederik, Desmet, Jan, Stockman, Kurt   +3 more
core  

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

FEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt, Manuela Gellert, Finja Zelms, Sander Bekeschus, Christopher Horst Lillig   +4 more
wiley   +1 more source

Research on the development path and countermeasures of data element value

大数据, 2023
Based on the development of data element marketization at home and abroad, the development path and characteristics of data element value in foreign countries were expounded.The current situation of China's data element market in terms of transaction ...
Yunlong YANG, Liang ZHANG, Xulei YANG
doaj