Results 121 to 130 of about 2,815,754 (290)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Remote SensingThis paper presents a method to improve ground elevation estimates through waveform analysis from the Global Ecosystem Dynamics Investigation (GEDI) and examines its impact on canopy height and aboveground biomass (AGB) estimation. The method uses a deep
Rei Mitsuhashi +7 more
doaj +1 more source
Issues in Science and Technology Librarianship, 2008 This article is the second part of the previously published review about the DOE Data Explorer database (Ayers 2008). It discusses the types of data that can be found using the Data Explorer by focusing on the content provided by the Data Resource Centers.
openaire +2 more sources
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Control-FREEC viewer: a tool for the visualization and exploration of copy number variation data
BMC BioinformaticsBackground Copy number alterations (CNAs) are genetic changes commonly found in cancer that involve different regions of the genome and impact cancer progression by affecting gene expression and genomic stability.
Valentina Crippa +3 more
doaj +1 more source
Visualization and data exploration of chromosome conformation capture data using Voronoi diagrams with v3c-viz. [PDF]
Sci Rep, 2023 Race AM, Fuchs A, Chung HR.
europepmc +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Univariate Panel Data Models and GMM Estimators: An Exploration Using Real and Simulated Data [PDF]
This paper explores the time series properties of commonly used variables in firm-level panels: sales (turnover), employment, R\&D, investment, and cash flow.
Bronwyn H. Hall, Jacques Mairesse
core
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source