China Geology: Since the first discovery of gold deposits on the northeastern margin of the Jiaolai Basin in Shandong Province at the end of the 20th century, seven medium-sized to large/super-large gold deposits have been identified in this region, with cumulative ...
Jun-wei Bo +5 more
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Teaching biology students data exploration and visualization in a data-driven world. [PDF]
Biochem Mol Biol Educ, 2022 Hilliker AK, Grayson KL.
europepmc +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Osteosarcoma transcriptome data exploration reveals STC2 as a novel risk indicator in disease progression. [PDF]
BMC Med Genomics, 2023 Wang Z +11 more
europepmc +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Approaches for value extraction on big data
大数据, 2017 The value of big data can be presented in different means，and therefore it has different ways to extract the value out of big data.Three approaches of value extraction on big data:data service，data analytics，and data exploration were summarized.The ...
Xiaoyong DU, Yueguo CHEN
doaj
The association between reallocations of time and health using compositional data analysis: a systematic scoping review with an interactive data exploration interface. [PDF]
Int J Behav Nutr Phys Act, 2023 Miatke A +8 more
europepmc +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Data Exploration and Classification of News Article Reliability: Deep Learning Study. [PDF]
JMIR Infodemiology, 2022 Zhan K, Li Y, Osmani R, Wang X, Cao B.
europepmc +1 more source