Results 81 to 90 of about 2,815,754 (290)
Frontiers in Digital HealthUnderstanding human behavior is a fundamental goal of social sciences, yet conventional methodologies are often limited by labor-intensive data collection and complex analyses.
Tobias Hallmen +7 more
doaj +1 more source
Exploring Data Analytics of Data Variety [PDF]
, 2018 The Internet allows organizations managers access to large amounts of data, and this data are presented in different formats, i.e., data variety, namely structured, semi-structured and unstructured. Based on the Internet, this data variety is partly derived from social networks, but not only, machines are also capable of sharing information among ...
Cruz, Tiago +2 more
openaire +2 more sources
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Exploring Scholarly Data with Rexplore [PDF]
, 2013 Despite the large number and variety of tools and services available today for exploring scholarly data, current support is still very limited in the context of sensemaking tasks, which go beyond standard search and ranking of authors and publications, and focus instead on i) understanding the dynamics of research areas, ii) relating authors ...
Osborne, Francesco +2 more
openaire +2 more sources
Interactive data exploration with targeted projection pursuit [PDF]
, 2009 Data exploration is a vital, but little considered, part of the scientific process; but few visualisation tools can cope with truly complex data. Targeted Projection Pursuit (TPP) is an interactive data exploration technique that provides an intuitive ...
Faith, Joe
core
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Using Multi-Layered Networks to Disclose Books in the Republic of Letters
Journal of Historical Network Research, 2017 This paper highlights the importance of books as dynamic actors within the Republic of Letters by means of multi-layered visualizations of epistolary networks.
Ingeborg van Vugt
doaj
Math and Data Exploration [PDF]
CBE—Life Sciences Education, 2010 Biology is well suited for mathematical description, from the perfect geometry of viruses, to equations that describe the flux of ions across cellular membranes, to computationally intensive models for protein folding. For this short Web review, however, I'm going to focus on how mathematics helps us as biologists sort, evaluate, and draw conclusions ...
openaire +2 more sources