Results 31 to 40 of about 2,138,949 (260)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
On Elaboration of the Method of Identifying Clusters Belonging to JPEG Files
Безопасность информационных технологий, 2014 The results of the experimental attempts of elaboration of the previously proposed method for identifying clusters belonging to JPEG files are described. Type II errors rates for different file formats are estimated.
Natalia Andreevna Kostilova +1 more
doaj
Practical Management of Heterogeneous Neuroimaging Metadata by Global Neuroimaging Data Repositories
Frontiers in Neuroinformatics, 2012 Rapidly evolving neuroimaging techniques are producing unprecedented quantities of digital data at the same time that many research studies are evolving into global, multi-disciplinary collaborations between geographically distributed scientists.
Scott eNeu +2 more
doaj +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
On Possible Expansion o f Data Carving for JPEG files Recovery
Безопасность информационных технологий, 2013 A possible application of the author’s method of differentiation of clusters belonging to JPEG files from other clusters on the digital media for expanding of existing data recovery methods is described in the work.
Alexander Vladimirovich Sorokin
doaj
A Usable Encryption Solution for File-Based Geospatial Data within a Database File System
Journal of Cybersecurity and PrivacyDeveloping a security solution for spatial files within today’s enterprise Geographical Information System (GIS) that is also usable presents a multifaceted challenge. These files exist in “data silos” of different file server types, resulting in limited
Pankajeshwara Sharma +2 more
doaj +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
CybersecurityRansomware attacks are increasingly prevalent in recent years. Crypto-ransomware corrupts files on an infected device and demands a ransom to recover them.
Josh Dafoe +3 more
doaj +1 more source
, 2022 The underlying data file includes dataset, questionnaire, informed consent, and participant information sheet.
Akthar, Nahima +2 more
openaire +1 more source