Results 161 to 170 of about 26,379,250 (355)

Federated learning for network attack detection using attention-based graph neural networks

open access: yesScientific Reports
Federated Learning is an effective solution to address the issues of data isolation and privacy leakage in machine learning. However, ensuring the security of network devices and architectures deploying federated learning remains a challenge due to ...
Wu Jianping   +4 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Considerations for enhancing situation assessment through multi-level fusion of hard and soft data

open access: yes, 2022
S.2133-2138This paper presents several lessons learned from the ongoing work of NATO IST-132 RTG-063 which is focused on data and information fusion incorporating structured and unstructured human generated information with device-generated data ...
Biermannn, J.   +4 more
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Computational modelling of the HyperVapotron cooling technique for nuclear fusion applications [PDF]

open access: yes, 2010
Efficient heat transfer technologies are essential for magnetically confined fusion reactors; this applies to both the current generation of experimental reactors as well as future power plants.
Milnes, Joseph
core  

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

open access: yesFEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj   +3 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

Merging probabilistic data of multiple targets detected by multiple sensors [PDF]

open access: yes, 2009
The aim of this work is to present an extension to current data fusion techniques and associated results for the implementation of a collaborative multi-platform, multi-target detection system. A multi-sighting data fusion algorithm has been simulated.
Tsourdos, Antonios   +3 more
core  

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

open access: yesFEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada   +5 more
wiley   +1 more source

Bayesian fusion: Modeling and application

open access: yes, 2013
6 S.Bayesian statistics leads to a powerful fusion methodology, especially for the fusion of heterogeneous information sources. If fusion problems are handled under consideration of the full expressiveness and the full range of methods provided by ...
Beyerer, Jürgen   +3 more
core   +1 more source

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