Results 91 to 100 of about 24,275,785 (260)
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Data imbalance in CRISPR off-target prediction
, 2019 For genome-wide CRISPR off-target cleavage sites (OTS) prediction, an important issue is data imbalance-the number of true OTS recognized by whole-genome off-target detection techniques is much smaller than that of all possible nucleotide mismatch loci ...
Gao, Yuli +4 more
core +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
This collection collects data from students about their academic and training activities at Tecnologico de Monterrey, from 1996 to date. It consists of 61 variables that are represented in different categories, such as: - Subject administration (school,
IFE Data Hub
core +1 more source
Quoted spreads and trade imbalance dynamics in the European treasury bond market [PDF]
, 2010 Using high-frequency transaction data for the three largest European markets (France, Germany and Italy), this paper documents the existence of an asymmetric relationship between market liquidity and trading imbalances: when quoted spreads rise (fall ...
Girardi, Alessandro +5 more
core +1 more source
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
Redressing the Rural-Urban Imbalance [PDF]
This paper focuses on rural poverty, its causes and effects, and suggests one of a number of possible measures to alleviate the problem. It examines why there exists an urban bias in development, and the impact it has on development patterns.
T. Scarlett Epstein
core
A Study on World Trade and Global Imbalance in the Inter-War Period : With a focus on trade and the balance of payments in Japan and China [PDF]
, 2011 P(論文)The inter-war period was a time of technological innovation; it was also a time of significant global imbalance. In the inter-war period, the new technological innovation created a new trade imbalance.
Shimpo, Hirohiko
core
Majority or Minority: Data Imbalance Learning Method for Named Entity Recognition
IEEE AccessData imbalance presents a significant challenge in various machine learning (ML) tasks, particularly named entity recognition (NER) within natural language processing (NLP).
Sota Nemoto +2 more
doaj +1 more source
Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy
Molecular Oncology, EarlyView.We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen +19 more
wiley +1 more source