Results 91 to 100 of about 505,761 (263)
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
FEBS Open Bio, EarlyView.Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya +2 more
wiley +1 more source
Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model
FEBS Open Bio, EarlyView.This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito +7 more
wiley +1 more source
Navigating Severe Class Imbalance in Population Cohort Data
2025 47th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)Class imbalance is a major challenge in predictive modelling for rare disease outcomes, particularly in large-scale population cohorts. Traditional machine learning models often struggle with imbalanced datasets, leading to biased performance metrics and poor generalisability.
Fieggen, J +6 more
openaire +2 more sources
Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Aging and Cancer, EarlyView.Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source
Data Augmentation in Solving Data Imbalance Problems
, 2020 Detta projekt fokuserar huvudsakligen på de olika metoderna för att lösa dataobalansproblem i fältet Natural Language Processing (NLP). Obalanserad textdata är ett vanligt problem i många uppgifter, särskilt klassificeringsuppgiften, vilket leder till att modellen inte kan förutsäga minoriteten Ibland kan vi till och med byta till en mer utmärkt och ...
openaire +1 more source
New Directions for Adult and Continuing Education, EarlyView.ABSTRACT This article examines the evolving role of organizational leadership amidst the rapid advancements in artificial intelligence (AI). It explores a broadly experienced and documented crisis in leadership, due in part to the disruptive nature of AI and emerging technology.
Rachel Wlodarsky, Davin Carr Chellman
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi +2 more
wiley +1 more source
Efficient Detection of Irrelevant User Reviews Using Machine Learning
Applied SciencesUser reviews such as SNS feeds and blog writings have been widely used to extract opinions, complains, and requirements about a given place or product from users’ perspective.
Cheolgi Kim, Hyeon Gyu Kim
doaj +1 more source
Research on data imbalance in intrusion detection using CGAN. [PDF]
PLoS One, 2023 Zhao G +5 more
europepmc +1 more source