Results 61 to 70 of about 505,761 (263)

A Dynamic Data-throttling Approach to Minimize Workflow Imbalance

ACM Transactions on Internet Technology, 2019
Scientific workflows enable scientists to undertake analysis on large datasets and perform complex scientific simulations. These workflows are often mapped onto distributed and parallel computational infrastructures to speed up their executions. Prior to its execution, a workflow structure may suffer transformations to accommodate the computing ...
Rodríguez, Ricardo J., Tolosana-Calasanz, Rafael, Rana, Omer F   +2 more
openaire   +3 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Patch-Based Semantically Enhanced Network for IR Dim and Small Targets Background Suppression

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
The task of background suppression in infrared small-target scenarios aims to eliminate irregular noisy backgrounds while preserving targets with high-frequency features.
Yunfei Tong, Yue Leng, Hai Yang, Zhe Wang, Saisai Niu, Huabao Long   +5 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Novel Deep Learning-Based Facial Forgery Detection for Effective Biometric Recognition

Applied Sciences
Advancements in science, technology, and computer engineering have significantly influenced biometric identification systems, particularly facial recognition. However, these systems are increasingly vulnerable to sophisticated forgery techniques.
Hansoo Kim
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Enhancing Intrusion Detection for IoT and Sensor Networks Through Semantic Analysis and Self-Supervised Embeddings

Sensors
As cyber threats continue to grow in complexity and sophistication, the need for advanced network and sensor security solutions has never been more urgent.
Yanshen Liu, Yinfeng Guo
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Data Level Approach for Multiclass Imbalance Financial Data

WSEAS TRANSACTIONS ON COMPUTERS, 2020
In the real world, the class imbalance problem is a common issue in which classifier gives more importance to the majority class whereas less importance to the minority class. In class imbalance, imbalance metrics would not be suitable to evaluate the performance of classifiers with error rate or predictive accuracy.
Nursel Selver Ruzgar, Clare Chua
openaire   +1 more source

Enhancing Predictive Accuracy in Medical Data Through Oversampling and Interpolation Techniques

Mathematics
Class imbalance is a major challenge in supervised classification, often leading to biased predictions and limited generalization. This issue is particularly pronounced in medical diagnostics, where datasets typically contain far more negative than ...
Alma Rocío Sagaceta-Mejía, Pedro Pablo González-Pérez, Julián Fresán-Figueroa, Máximo Eduardo Sánchez-Gutiérrez   +3 more
doaj   +1 more source