Results 111 to 120 of about 179,516 (314)
Isolation Defines Identity: Functional Consequences of Extracellular Vesicle Purification Strategies
Advanced Healthcare Materials, EarlyView.Four extracellular vesicle purification strategies are compared using ovarian‐cancer ascites and ES‐2 cell supernatants. A novel workflow links purification to function by combining particle‐normalized proteomics with matched cell‐free and cell‐based assays.
Christian Preußer +10 more
wiley +1 more source
Multiple Imputation for Handling Missing Data of Covariates in Meta-Regression
, 2021 Diaz Yanez
openalex +1 more source
Quantum Electrometry of Non‐Volatile Space Charges in Diamond
Advanced Optical Materials, EarlyView.Charges are generated when nitrogen vacancy qubits in diamond are illuminated by light. Transport and trapping in an electric field leads to the formation of large, stable space charge patterns that dynamically screen applied electric fields, impacting electric field sensing and photoelectric detection.
Russell M Goldblatt +4 more
wiley +1 more source
Addressing Missing Data in Untargeted Metabolomics: Identifying Missingness Type and Evaluating the Impact of Imputation Methods on Experimental Replication [PDF]
, 2021 Trenton J. Davis +4 more
openalex +1 more source
Advanced Science, EarlyView.This study presents a machine‐learning framework entitled MERLIN that infers the microanatomical localization of macrophages from single‐cell transcriptomic data in structured organs such as the kidney and brain. Applying this method to existing datasets from models of acute kidney injury and diabetic nephropathy uncovered spatially resolved insights ...
Junping Yin +18 more
wiley +1 more source
Advanced Science, EarlyView.Aldosterone‐producing adenomas (APAs) develop via two distinct paths: directly from adrenal zona glomerulosa (zG) cells, or stepwise from zG cells through aldosterone‐producing micronodules (APMs) before progressing to APAs. Advanced single‐cell and spatial analyses identified distinct cell states linked to oxidative stress and cell–cell interactions ...
Zhuolun Sun +7 more
wiley +1 more source
A Mussel‐Inspired Bioadhesive Patch to Selectively Kill Glioblastoma Cells
Advanced Science, EarlyView.An innovative mussel‐inspired bioadhesive patch has been developed for post‐surgical glioblastoma treatment. The patch, which adheres strongly in biological environments, releases a localized treatment. This treatment, acting via reactive oxygen species, shows specific toxicity to glioblastoma cells.
Jose Bolaños‐Cardet +5 more
wiley +1 more source
PLoS Computational Biology, 2020 Genotype imputation estimates the genotypes of unobserved variants using the genotype data of other observed variants based on a collection of haplotypes for thousands of individuals, which is known as a haplotype reference panel.
Kaname Kojima +6 more
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Anomaly Detection Using a Sliding Window Technique and Data Imputation with Machine Learning for Hydrological Time Series [PDF]
, 2021 Lattawit Kulanuwat +6 more
openalex +1 more source
MGM as a Large‐Scale Pretrained Foundation Model for Microbiome Analyses in Diverse Contexts
Advanced Science, EarlyView.We present the Microbial General Model (MGM), a transformer‐based foundation model pretrained on over 260,000 microbiome samples. MGM learns contextualized microbial representations via self‐supervised language modeling, enabling robust transfer learning, cross‐regional generalization, keystone taxa discovery, and prompt‐guided generation of realistic,
Haohong Zhang +5 more
wiley +1 more source