Results 181 to 190 of about 4,439,564 (294)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Corrigendum to "Expedited modeling of burn events results (EMBER): A screening-level dataset of 2023 ozone fire impacts in the US" [Data in Brief (2025) article number 111208]. [PDF]

Data Brief
Simon H, Beidler J, Baker KR, Henderson BH, Fox L, Misenis C, Campbell P, Vukovich J, Possiel N, Eyth A.   +9 more
europepmc   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Corrigendum to "Isotopic insights from carpological remains: One of the first datasets for the Italian Bronze age" [Data in brief 57 (2024) 111000]. [PDF]

Data Brief
Cortese F, De Angelis F, Bontempo L, Carrara N, Cuda MT, Longa ED, Cecchi IM, Sarti L, Silvestri L, Rickards O, Rolfo MF.   +10 more
europepmc   +1 more source

Data in Brief of: Clinical benefits of moxifloxacin as initial treatment of community-acquired pneumonia: Data from meta-analyses. [PDF]

Data Brief, 2021
Du X, Han Y, Jian Y, Chen L, Xuan J.
europepmc   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Corrigendum to "Data supporting UCrad and CGM, two novel methodologies for radiological impacts in life cycle assessment" [Data in Brief 28 (2020) 104857]. [PDF]

Data Brief
Paulillo A, Clift R, Dodds J, Milliken A, Palethorpe S, Lettieri P.   +5 more
europepmc   +1 more source

Corrigendum to 'The hardships of the poorest during the COVID-19 pandemic: Data about the socioeconomic conditions and governance of informal workers' Data in Brief [Volume 40, February 2022, 107,728]. [PDF]

Data Brief, 2022
Martínez L, Young G, Trofimoff V, Valencia I, Vidal N, Espada AD, Robles E.   +6 more
europepmc   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Class Enumeration in Mixture Modeling with Nested Data: A Brief Report. [PDF]

J Exp Educ
Musci RJ, Kush J, Pas ET, Bradshaw CP.
europepmc   +1 more source