Results 181 to 190 of about 1,433,367 (217)

Enhancing diabetes risk stratification through natural language processing: a multimodal data integration approach. [PDF]

Front Public Health
Lu Y, Li T, Ge L, Wei Y, Li Y, Huang S, Jiang T, Chen Y, Xiang Z.   +8 more
europepmc   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

SCMBench: benchmarking domain-specific and foundation models for single-cell multi-omics data integration. [PDF]

Nat Commun
Wang Y, Fan Y, Wang X, Yu T, Zong Y, Liu X, Zhong G, Liu M, Li Q, Lee KH, Dallakyan K, Hu Z, Qi Y, Huang J, Jia G, Yuan J, Chan TF, Gao X, King I, Li Y.   +19 more
europepmc   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Impact of Laboratory Data Integration into Outpatient Prescriptions on Community Pharmacist Feedback and Physician Responses: A Single-Center Retrospective Study. [PDF]

Risk Manag Healthc Policy
Motoki T, Tanaka H, Tai T, Yamaguchi K, Kosaka S, Mino Y.   +5 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Multimodal data integration and machine learning methods for early detection and risk prediction of pulmonary diseases in athletes. [PDF]

Front Med (Lausanne)
Zhang R, Chang Q.
europepmc   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Experiences from national biodiversity data infrastructures in Europe: advancing data integration and community engagement. [PDF]

Bioscience
Gemeinholzer B, Bonn A, Ebert B, Fischer S, Güntsch A, Holetschek J, Johansson VA, Friedrichs-Manthey M, Röder J, Schomburg C, Steinthorsdottir M, van Ommen Kloeke E, de Boer HJ.   +12 more
europepmc   +1 more source