Results 111 to 120 of about 3,968,782 (301)

Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance

Molecular Oncology, EarlyView.
Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren, Kathryn A. Wierenga, Frank M. Riemers, Elsbeth A. van Liere, Bart Westendorp   +4 more
wiley   +1 more source

Estudo da ocorrência de meningite meningocócica em região meridional do Brasil, de 1974 a 1980, utilizando o modelo ponto evento The occurrence of meningococcal meningitis in a Southern region of Brazil, from 1974 to 1980, a point event model study

Revista de Saúde Pública, 1991
Técnicas de estatística descritiva e métodos do modelo ponto evento foram utilizados para estudar-se séries temporais de meningite meningocócica de 100 municípios do Estado do Rio Grande do Sul, Brasil, no período de 1974 a 1980. Os dados foram separados
David Sérgio Adães de Gouvêa, Flávio Fonseca Nobre   +1 more
doaj   +1 more source

Analyses and Concerns in Precision Medicine: A Statistical Perspective [PDF]

arXiv
This article explores the critical role of statistical analysis in precision medicine. It discusses how personalized healthcare is enhanced by statistical methods that interpret complex, multidimensional datasets, focusing on predictive modeling, machine learning algorithms, and data visualization techniques.
arxiv  

An approximation theoretic perspective of the Sobol' indices with dependent variables [PDF]

arXiv, 2017
The Sobol' indices are a recognized tool in global sensitivity analysis. When the uncertain variables in a model are statistically independent, the Sobol' indices may be easily interpreted and utilized. However, their interpretation and utility is more challenging with statistically dependent variables.
arxiv  

Quark gluon plasma in a + a collisions at CERN SPS [PDF]

, 2005
A brief review of a history of data collection and interpretation of the results on high energy A+A collisions is presented. Basic assumptions and main results of a statistical model of the early stage of the A+A collisions are discussed. It is concluded
Gazdzicki, Marek
core  

Classification of acute myeloid leukemia based on multi‐omics and prognosis prediction value

Molecular Oncology, EarlyView.
The Unsupervised AML Multi‐Omics Classification System (UAMOCS) integrates genomic, methylation, and transcriptomic data to categorize AML patients into three subtypes (UAMOCS1‐3). This classification reveals clinical relevance, highlighting immune and chromosomal characteristics, prognosis, and therapeutic vulnerabilities.
Yang Song, Zhe Wang, Guangji Zhang, Jiangxue Hou, Kaiqi Liu, Shuning Wei, Yan Li, Chunlin Zhou, Dong Lin, Min Wang, Hui Wei, Jianxiang Wang, Tao Cheng, Yingchang Mi   +13 more
wiley   +1 more source

Statistical Significance versus Clinical Relevance: Key Considerations in Interpretation Medical Research Data

Indian Journal of Community Medicine
Medical research plays a crucial role in advancing our understanding of various aspects related to health, including disease, risk factors, and patient management.
Yousif AbdulRaheem
doaj   +1 more source

Uso da imputação múltipla de dados faltantes: uma simulação utilizando dados epidemiológicos Multiple imputations for missing data: a simulation with epidemiological data

Cadernos de Saúde Pública, 2009
Em situações com dados faltantes, é comum restringir-se à análise dos sujeitos com dados completos. Porém, as estimativas com apenas esses sujeitos podem tornar-se viesadas.
Luciana Neves Nunes, Mariza Machado Klück, Jandyra Maria Guimarães Fachel   +2 more
doaj   +1 more source

Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi, Eric Feng, Nicholas R. Rydzewski, Amy K. Taylor, Jamie M. Sperger, Yue Shi, Kyle T. Helzer, Matthew L. Bootsma, Viridiana Carreno, Alex H. Chang, Luke A. Nunamaker, Grace C. Blitzer, Tianfu Andy Shang, Aishwarya Subramanian, Anders Bjartell, Andreas Josefsson, Pernilla Wikström, Emily Feng, Manish Kohli, Rendong Yang, Scott M. Dehm, Eric J. Small, Rahul Aggarwal, David A. Quigley, Joshua M. Lang, Shuang G. Zhao, Martin Sjöström   +26 more
wiley   +1 more source

PhenoMeter: a metabolome database search tool using statistical similarity matching of metabolic phenotypes for high-confidence detection of functional links

Frontiers in Bioengineering and Biotechnology, 2015
This article describes PhenoMeter, a new type of metabolomics database search that accepts metabolite response patterns as queries and searches the MetaPhen database of reference patterns for responses that are statistically significantly similar or ...
Adam James Carroll, Peng eZhang, Lynne eWhitehead, Sarah eKaines, Guillaume eTcherkez, Murray Ronald Badger   +5 more
doaj   +1 more source