Results 211 to 220 of about 3,498,601 (287)

Heterogeneity in meta-analysis: a path toward more meaningful clinical evidence. [PDF]

Korean J Anesthesiol
Lee S.
europepmc   +1 more source

Cognitive Resilience in Apolipoprotein ε4 Carrier Women Predicted by Neuron‐Derived Extracellular Vesicles

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The Apolipoprotein (APOE) ε4 allele is the strongest genetic risk factor for late‐onset Alzheimer's disease (AD); however, many ε4 carriers remain cognitively intact into old age. Leveraging plasma neuron‐derived extracellular vesicles (NDEVs), we sought to identify biomarkers of cognitive resilience and their interplay with APOE ...
Apostolos Manolopoulos, Maja Mustapic, Carlos Nogueras‐Ortiz, Francheska Delgado‐Peraza, Krishna A. Pucha, Pamela J. Yao, Joseph Blommer, Michael P. Vreones, William York, De' Larrian Knight, Stephen R. Rapp, Aladdin H. Shadyab, JoAnn E. Manson, Ramon Casanova, Robert B. Wallace, Luigi Ferrucci, Susan M. Resnick, Dimitrios Kapogiannis   +17 more
wiley   +1 more source

Evaluation of the impact of artificial intelligence-assisted image interpretation on the diagnostic performance of clinicians in identifying endotracheal tube position on plain chest X-ray: a multi-case multi-reader study. [PDF]

Crit Care
Novak A, Ather S, Morgado ATE, Maskell G, Cowell GW, Black D, Shah A, Bowness JS, Shadmaan A, Bloomfield C, Oke JL, Johnson H, Beggs M, Gleeson F, Aylward P, Hafeez A, Elramlawy M, Lam K, Griffiths B, Harford M, Aaron L, Seeley C, Luney M, Kirkland J, Wing L, Qamhawi Z, Mandal I, Millard T, Chimbani M, Sharazi A, Bryant E, Haithwaite W, Medonica A.   +32 more
europepmc   +1 more source

Associations of Stroke With Risk of Epilepsy: Results From the Atherosclerosis Risk in Communities (ARIC) Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To estimate the risk of epilepsy associated with stroke in a community‐based cohort, with consideration of stroke type, number, and severity. Methods Data from 15,100 Atherosclerosis Risk in Communities (ARIC) Study participants without stroke at baseline (1987–1989) were analyzed through 12/31/2022.
Jiping Zhou, Asma A. Ladak, Connor A. Law, Michelle C. Johansen, Anny Reyes, Silvia Koton, Sean Kelly, Jeubin Huang, Kamakshi Lakshminarayan, Rebecca F. Gottesman, Emily Johnson, Andrea L. C. Schneider   +11 more
wiley   +1 more source

Efficient statistical analysis of trial designs: win ratio and related approaches for composite outcomes. [PDF]

Perioper Med (Lond)
Fandino W, Dodd M, Kunst G, Clayton T.
europepmc   +1 more source

Exploring if Longitudinal Changes on PET Imaging Can Serve as a Biomarker for Stiff Person Syndrome Spectrum Disorders

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To identify metabolic patterns in the brain and musculoskeletal system of stiff person syndrome spectrum disorders (SPSD) patients over time using PET imaging and evaluate the impact of immune therapy on metabolic activity as a surrogate for treatment response.
Munther M. Queisi, Samantha N. Roman, Mohammad S. Sadaghiani, Lilja B. Solnes, Scott D. Newsome   +4 more
wiley   +1 more source

A randomized clinical trial of silver hydrofiber dressing versus collagenase ointment for venous ulcer: analysis of biofilm-producing bacteria and bacterial clonality. [PDF]

An Bras Dermatol
Saranholi TL, Sampaio NCFM, Miot HA, Dantas STA, Rall VLM, Abbade LPF.   +5 more
europepmc   +1 more source

NOTCH2NLC Repeat Expansions in Parkinsonian Disorders: Clinical and Neuroimaging Characteristics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neuronal intranuclear inclusion disease (NIID) is a neurodegenerative disorder caused by NOTCH2NLC GGC repeat expansions, with heterogeneous clinical manifestations, including parkinsonism. Recent studies have identified NOTCH2NLC repeat expansions in patients with Parkinson's disease (PD) and atypical parkinsonism (aPM), suggesting ...
Han‐Lin Chiang, Kang‐Yang Jih, Cheng‐Tsung Hsiao, Fu‐Pang Chang, Justus Chunyu Chen, Yi‐Chu Liao, Yih‐Ru Wu, Yi‐Chung Lee   +7 more
wiley   +1 more source

Elucidating the Role of <i>KRAS</i>, <i>NRAS</i>, and <i>BRAF</i> Mutations and Microsatellite Instability in Colorectal Cancer via Next-Generation Sequencing. [PDF]

Cancers (Basel)
Rodríguez MR, Biedma BA, Rodríguez Pérez I, Romeo JA.   +3 more
europepmc   +1 more source

Central Dysmyelination in SSADH‐Deficient Humans and Mice

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Succinic semialdehyde dehydrogenase deficiency (SSADHD) is an inherited metabolic disorder characterized by an accumulation of γ‐aminobutyric (GABA). In addition to its synaptic role as an inhibitory neurotransmitter, GABA also plays an important role in myelination.
Itay Tokatly Latzer, Henry H. C. Lee, Edward Yang, Cesar Alves, Mariarita Bertoldi, Caitlyn Fung, Spencer V. Steele, Eren Kule, Zijie Jin, Alexander Rotenberg, Jean‐Baptiste Roullet, Phillip L. Pearl   +11 more
wiley   +1 more source