Results 241 to 250 of about 1,676,124 (274)

Sex Representation in US Stroke Clinical Trials: A Decade of Trends and Challenges

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Stroke remains a major cause of disability and mortality in the US, with significant sex‐based disparities, and females remain underrepresented in stroke clinical trials. We aimed to examine sex representation in US‐based stroke clinical trials, identify trial characteristics associated with higher female enrollment (≥ 50%), and ...
Chaitali Dagli, Mudasir Andrabi, Tova Cohen, Pranali G. Patel, Tapasya Katta, Chen Lin   +5 more
wiley   +1 more source

Exploratory analyses of clinical trials - what can they tell us and what are the potential pitfalls? [PDF]

Nat Commun
europepmc   +1 more source

Dorsal bridge plating, volar plating, or both? A retrospective analysis of clinical and radiographic outcomes of intraarticular distal radius fracture fixation techniques. [PDF]

Eur J Orthop Surg Traumatol
Litten R, Wilson A, Yeager M, Rutz R, McIlwain R, Frith K, Quade J.   +6 more
europepmc   +1 more source

Onasemnogene Abeparvovec in Type I Spinal Muscular Atrophy: 24‐Month Follow‐Up From the Italian Registry

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Onasemnogene abeparvovec (OA) is an AAV9‐based gene therapy for spinal muscular atrophy type I (SMA I). Real‐world outcomes show increased response variability compared to clinical trials, and follow‐up data beyond 12–18 months are limited.
Marika Pane, Giorgia Coratti, Chiara Cutrì, Antonio Varone, Riccardo Masson, Adele D'Amico, Valeria Sansone, Sonia Messina, Federica Ricci, Chiara Ticci, Claudio Bruno, Caterina Agosto, Francesca Benedetti, Antonella Pini, Sabrina Siliquini, Massimiliano Filosto, Alberto Zambon, Ilaria Bitetti, Maria Rosaria Manna, Claudia Dosi, Riccardo Zanin, Stefano Parravicini, Roberto De Sanctis, Giulia Stanca, Michela Catteruccia, Michele Tosi, Irene Mizzoni, Emilio Albamonte, Valentina Franchino, Maria Sframeli, Ilaria Cavallina, Elena Procopio, Michele Sacchini, Simone Morando, Noemi Brolatti, Federica Trucco, Gaia Scarpini, Elena Briganti, Beatrice Berti, Concetta Palermo, Daniela Leone, Stefano C. Previtali, Eugenio Mercuri, the ITASMAC working group   +43 more
wiley   +1 more source

IL18 gene variants rs187238 and rs360717 and their associations with psoriasis susceptibility and severity in a Brazilian case-control study. [PDF]

An Bras Dermatol
Moreira CR, Reiche EMV, Lozovoy MAB, Simão ANC.   +3 more
europepmc   +1 more source

Quantifying the Impact of Ocrelizumab on Paramagnetic Rim Lesions in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Paramagnetic rim lesions (PRLs) are a subset of chronic active multiple sclerosis (MS) lesions marked by iron‐laden microglia and macrophages. Ocrelizumab, a monoclonal antibody targeting CD20+ B cells, suppresses acute MS activity, but its effect on PRLs remains unclear. In a longitudinal study of 29 ocrelizumab‐treated patients with at least
Kimberly H. Markowitz, Neha V. Safi, Iliana Pliska‐Bloch, Ulrike W. Kaunzner, Ha Luu, Mert Sisman, Yi Wang, Thanh D. Nguyen, Sandra Hurtado Rúa, Susan A. Gauthier   +9 more
wiley   +1 more source

Optimising POU3F4 variant interpretation through gene-specific evidence in X-linked hearing loss. [PDF]

EBioMedicine
Geng J, Zhao Y, Huang Y, Xiong W, Zhong M, Wang C, Wang X, Zhang Q, Tang T, Chen M, Fang L, Yang Y, Bu F, Cheng J, Lu Y, Yuan H.   +15 more
europepmc   +1 more source

Association between Serum Vitamin D Levels and <i>VDR</i> <i>BsmI</i> Polymorphism in Temporomandibular Joint Dysfunction Patients (in the Iranian Population). [PDF]

J Dent (Shiraz)
Mostafavi M, Rezazadeh F, Fattahi MJ, Tavakoli F, Ghaderi A.   +4 more
europepmc   +1 more source

A Conceptual Wound-Oriented Reinterpretation of Perfusion Heterogeneity in Chronic Limb-Threatening Ischemia. [PDF]

J Clin Med
Popitiu MI, Patrone L, Clerici G, Comsa S, Gavrila-Ardelean G, Kundnani NR, Olariu N, Ionac ME.   +7 more
europepmc   +1 more source

Enhancing Preclinical Rigor: Evaluating Robustness and Numerical Stability in a Chronic Pancreatitis Mouse Model. [PDF]

Ann N Y Acad Sci
Thämlitz A, Khan MI, Schulz B, Pilch L, Vollmar B, Zechner D.   +5 more
europepmc   +1 more source