Results 21 to 30 of about 3,166,032 (228)

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis

FEBS Letters, EarlyView.
Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner, Juthamas Khamseekaew, M. Gregor Madej, Linda Geiges, Bardha Azemi, Christine Ziegler, Christoph Korbmacher, Alexandr V. Ilyaskin   +7 more
wiley   +1 more source

Statistical approach for unpolarized fragmentation functions for the octet baryons

, 2003
A statistical model for the parton distributions in the nucleon has proven its efficiency in the analysis of deep inelastic scattering data, so we propose to extend this approach to the description of unpolarized fragmentation functions for the octet ...
A. D. Martin, B. Q. Ma, B.-Q. Ma, B.-Q. Ma, B.-Q. Ma, B.-Q. Ma, B.-Q. Ma, C. Boros, C. Bourrely, C. Bourrely, C. Bourrely, Claude Bourrely, D. Buskulic, D. de Florian, D. Indumathi, G. Alexander, G. Alexander, G. Altarelli, G. Gurci, H. Aihara, H. J. Behrend, H. L. Lai, J. Binnewies, J.-J. Yang, J.-J. Yang, Jacques Soffer, K. Abe, K. Ganesamurtly, M. Acciari, M. Althoff, M. Althoff, M. Arneodo, M. Derrick, M. Glück, M. Glück, M. Glück, M. Stratmann, P. Abreu, P. Abreu, P. Abreu, P. Baringer, P. J. Rijken, R. Barate, R. Brandelik, R. S. Bhalerao, R. S. Bhalerao, R. S. Bhalerao, S. Belostotski, S. J. Brodsky, S. Kretzer, T. Gehrmann, T. L. Geld, V. Devanathan, V. Devanathan, V. N. Gribov, V. N. Gribov, W. Braunschweig, W. Braunschweig, W. Furmanski, W. Furmanski   +59 more
core   +2 more sources

P‐glycoprotein modulates the fluidity gradient of the plasma membrane of multidrug resistant CHO cells

FEBS Letters, EarlyView.
To explore the impact of the overexpression of the multidrug‐transporter P‐glycoprotein (ABCB1) on membrane fluidity, we compared the transversal gradient of mobility and microviscosity in plasma membranes of drug‐sensitive Chinese hamster ovary cells (AuxB1) and their multidrug‐resistant derivatives (B30) using the fluorescent n‐(9‐anthroyloxy) fatty ...
Roger Busche, John R. Riordan, Burkhard Tümmler   +2 more
wiley   +1 more source

Identification of functional and diverse circulating cancer‐associated fibroblasts in metastatic castration‐naïve prostate cancer patients

Molecular Oncology, EarlyView.
Cancer‐associated fibroblasts (CAFs) promote cancer growth, invasion (metastasis), and drug resistance. Here, we identified functional and diverse circulating CAFs (cCAFs) in patients with metastatic prostate cancer (mPCa). cCAFs were found in higher numbers and were functional and diverse in mPCa patients versus healthy individuals, suggesting their ...
Richell Booijink, Leon W. M. M. Terstappen, Eshwari Dathathri, Khrystany Isebia, Jaco Kraan, John Martens, Ruchi Bansal   +6 more
wiley   +1 more source

Circulating tumor cells in metastatic breast cancer patients treated with immune checkpoint inhibitors – a biomarker analysis of the ALICE and ICON trials

Molecular Oncology, EarlyView.
In this explorative biomarker analysis, we assessed serial sampling of circulating tumor cells (CTCs) with CellSearch in two randomized trials testing immune checkpoint inhibitors (ICIs) in metastatic breast cancer. Our data demonstrate a prognostic potential of CTCs, most apparent 4 weeks into ICI therapy.
Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Elin Borgen, Cecilie Bendigtsen Schirmer, Bjørnar Gilje, Øystein Garred, Jon Lømo, Marius Stensland, Oddmund Nordgård, Ragnhild Sørum Falk, Randi R. Mathiesen, Hege G. Russnes, Jon Amund Kyte, Bjørn Naume   +13 more
wiley   +1 more source

Reliable and accurate diagnostics from highly multiplexed sequencing assays [PDF]

, 2020
Scalable, inexpensive, and secure testing for SARS-CoV-2 infection is crucial for control of the novel coronavirus pandemic. Recently developed highly multiplexed sequencing assays (HMSAs) that rely on high-throughput sequencing can, in principle, meet ...
Bloom, Joshua S., Booeshaghi, A. Sina, Cooper, Aaron R., Gehring, Jase, Kosuri, Sriram, Lubock, Nathan B., Luebbert, Laura, Pachter, Lior, Simpkins, Scott W.   +8 more
core  

Statistical outliers in random laser emission [PDF]

, 2018
We provide theoretical and experimental evidence of statistical outliers in random laser emission that are not accounted for by the, now established, power-law tailed (L\'evy) distribution.
Cavalieri, Stefano, Fini, Lorenzo, Ignesti, Emilio, Lepri, Stefano, Martelli, Fabrizio, Tommasi, Federico   +5 more
core   +2 more sources

A comparative study of circulating tumor cell isolation and enumeration technologies in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells were spiked into donor blood to evaluate the recovery rates of the following circulating tumor cell (CTC) enrichment technologies: CellMag™, EasySep™, RosetteSep™, Parsortix® PR1, and Parsortix® Prototype systems. Each method's advantages and disadvantages are described.
Volga M Saini, Ezgi Oner, Mark P. Ward, Sinead Hurley, Brian David Henderson, Faye Lewis, Stephen P. Finn, Gerard J. Fitzmaurice, John J. O'Leary, Sharon O'Toole, Lorraine O'Driscoll, Kathy Gately   +11 more
wiley   +1 more source

Multivariate statistical interpretation of laboratory clinical data

Open Medicine, 2007
Abstract Laboratory aids are extensively used in the diagnosis of diseases, in preventive medicine, and as management tools. Reference values of clinically healthy people serve as a guide to the clinician in evaluating biochemical parameters. Determination of 21 biochemical parameters of healthy persons using standard methods of analysis.
Eleni Dovriki, Thomas Spanos, Agelos Papaioannou, Vasili Simeonov, Panagiotis Plageras   +4 more
openaire   +3 more sources