Results 81 to 90 of about 3,493,323 (251)

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Verifying Accuracy of Data Registration in Households\' Files Living in Rural Areas of Hamadan County in 2011

پزشکی بالینی ابن سینا, 2013
Introduction & Objective: Initial information is necessary for decision and policy making. A weak information system leads to poor decision-making but the accuracy of data registration and collection can be a valid supporter for assessing health system ...
Alireza Soltanian, Naser Fayyazi, Farah Khodakarami, Mahdi Maleki   +3 more
doaj  

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Análisis interino en ensayos clínicos: un estudio meta-epidemiológico

Medicina U.P.B., 2017
Objetivo: la responsabilidad ética del investigador obliga al monitoreo de la seguridad de los participantes a través del estudio y, por ende, se requiere de un comité de moni-toreo de datos, cuya tarea principal es el análisis interino que se refiere a ...
Laura Acevedo Ortiz, Daniela Jaramillo Velásquez, Jorge Hernando Donado Gómez   +2 more
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Statistical Significance versus Clinical Relevance: Key Considerations in Interpretation Medical Research Data

Indian Journal of Community Medicine
Medical research plays a crucial role in advancing our understanding of various aspects related to health, including disease, risk factors, and patient management.
Yousif AbdulRaheem
doaj   +1 more source

A phase space approach to supercooled liquids and a universal collapse of their viscosity

Frontiers in Materials, 2016
A broad fundamental understanding of the mechanisms underlying the phenomenology of supercooled liquids has remained elusive, despite decades of intense exploration.
Nicholas Bryan Weingartner, Flavio Nogueira, Chris Pueblo, Kenneth Kelton, Zohar Nussinov   +4 more
doaj   +1 more source

Likelihood-based statistical estimation from quantized data [PDF]

Most standard statistical methods treat numerical data as if they were real (infinitenumber- of-decimal-places) observations. The issue of quantization or digital resolution is recognized by engineers and metrologists, but is largely ignored by ...
Lee, Chiang-Sheng, Vardeman, Stephen B.
core  

Schroedinger's Interpolating Dynamics and Burgers' Flows

, 1997
We discuss a connection (and a proper place in this framework) of the unforced and deterministically forced Burgers equation for local velocity fields of certain flows, with probabilistic solutions of the so-called Schr\"{o}dinger interpolation problem ...
Albeverio, Beck, Blanchard, Burgers, Calderoni, Fleming, Friedman, Föllmer, Garbaczewski, Garbaczewski, Garbaczewski, Garbaczewski, Garbaczewski, Garbaczewski, Grzegorz Kondrat, Hasegawa, Haussmann, Hopf, Horsthemke, Jamison, Kac, Krzyzański, Lasota, Mackey, McKean, Mikami, Nelson, Nelson, Osada, Piotr Garbaczewski, Robert Olkiewicz, Schrödinger, Shandarin, Zambrini   +33 more
core   +1 more source