Results 151 to 160 of about 27,284,480 (302)

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Imaging-Based Spatial Transcriptomics: Data Interpretation Methods and Biomedical Applications. [PDF]

Biology (Basel)
Li W, Zhou Y.
europepmc   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Methodological guidelines for P2X receptor assays and data interpretation. [PDF]

Cell Death Dis
Gorecki DC, Adinolfi E, Adriouch S, Coutinho-Silva R, Engel T, Gölöncsér F, Haag F, Illes P, Jacobson KA, Koch-Nolte F, Mansoor SE, Matute C, Melino G, Novak I, Pegoraro A, Pelegrin P, Piacentini M, Robson SC, Rumney RMH, Seman M, Sluyter R, Sperlagh B, Tang Y, Tarantini M, Ulrich H, Vouret-Craviari V, Ye Q, Yegutkin GG, Verkhratsky A.   +28 more
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Data Interpretation Paradoxes in a Nanoencapsulated α-Mangostin Hydrogel Film for Anti-Acne Therapy [Response to Letter]. [PDF]

Drug Des Devel Ther
Yuniarsih N, Chaerunisaa AY, Mohammed AFA, Elamin KM, Muchtaridi M, Wathoni N.   +5 more
europepmc   +1 more source

Targeted proteomics data interpretation with DeepMRM. [PDF]

Cell Rep Methods, 2023
Park J, Wilkins C, Avtonomov D, Hong J, Back S, Kim H, Shulman N, MacLean BX, Lee SW, Kim S.   +9 more
europepmc   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Data Interpretation Paradoxes in a Nanoencapsulated α-Mangostin Hydrogel Film for Anti-Acne Therapy [Letter]. [PDF]

Drug Des Devel Ther
Xiao Z, Tan Y.
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source