Results 181 to 190 of about 5,937,551 (333)

Identifying prognostic targets in metastatic prostate cancer beyond AR

FEBS Open Bio, EarlyView.
Genome‐wide functional screens combined with a large gene expression database and clinical outcomes can identify new therapeutic vulnerabilities in prostate cancer. Eight potentially druggable targets demonstrated strong dependency in cell lines, were associated with worse prognosis clinically, and showed evidence of protein expression in prostate ...
Emily Feng, Eric Feng, Tracy Berg, Isabella S. Nguyen, Lilac G. Nguyen, William Chen, Meng Zhang, David Quigley, Marina Sharifi, Haolong Li, Ilsa Coleman, Peter S. Nelson, Martin Sjöström, Shuang G. Zhao   +13 more
wiley   +1 more source

Construction of hyperthermostable d‐allulose 3‐epimerase from Arthrobacter globiformis M30 using the sequence information from Arthrobacter psychrolactophilus

FEBS Open Bio, EarlyView.
d‐Allulose can be produced from d‐fructose by d‐allulose 3‐epimerase. Based on sequence homology information, we successfully engineered thermostable mutants with the protein engineering method. By integrating positive mutations, we constructed an enzyme that exhibits hyperthermostability without a loss in the activity.
Kensaku Shimada, Kouhei Ohtani, Pushpa Kiran Gullapalli, Kazuhiko Ishikawa   +3 more
wiley   +1 more source

Development of a core set of gait features and their potential underlying impairments to assist gait data interpretation in children with cerebral palsy. [PDF]

Front Hum Neurosci, 2022
van der Krogt MM, Houdijk H, Wishaupt K, van Hutten K, Dekker S, Buizer AI.   +5 more
europepmc   +1 more source

An experiment in cultural interpretation and map revision from Skylab data [PDF]

The author has identified the following significant results. S190-A imagery is suitable for input to map compilation and revision at scales from 1:1,000,000 to 1:250 ...
Kosco, W. J.
core   +1 more source

Earthing effects on mitochondrial function: ATP production and ROS generation

FEBS Open Bio, EarlyView.
In contrast to sham and naive controls, grounded mitochondria not only exhibit significantly enhanced energy production but also demonstrate a remarkable reduction in membrane potential and oxidative stress. This suggests a profound improvement in mitochondrial health, presenting a promising avenue for therapeutic interventions.
Cecilia Giulivi, Richard Kotz
wiley   +1 more source

Potential pitfalls in analysing a SARS-CoV-2 RT-PCR assay and how to standardise data interpretation. [PDF]

J Virol Methods, 2022
Smith M, El Bouzidi K, Bengen S, Cohen A, Zuckerman M.   +4 more
europepmc   +1 more source

Biophysical characterization and ion transport with cell‐based and proteoliposome reconstitution assays of invertebrate K+‐Cl− cotransporters

FEBS Open Bio, EarlyView.
The K+‐Cl− cotransporters (KCCs) facilitate the symport of ions across the plasma membrane. They participate in physiological processes including neuronal regulation. Here, we characterized KCCs from Drosophila and Hydra vulgaris. Comparative analyses of transporters provide insights into the mechanism of KCC ion transport, regulation, and evolution ...
Satoshi Fudo, Marina Verkhovskaya, Coralie Di Scala, Claudio Rivera, Tommi Kajander   +4 more
wiley   +1 more source

Preliminary interpretation of aeromagnetic and gravity data near the Large Aperture Seismic Array, Montana [PDF]

, 1968
Isidore Zietz, B. Carter Hearn, Donald Plouff   +2 more
openalex   +1 more source

Measuring. Monitoring. Management. Control

Измерение, мониторинг, управление, контроль
Background. The emergence and importance of the research topic is substantiated by the colossal growth in the volume of accumulated and underprocessed medical information, the evolution of mathematical and algorithmic apparatus, and the need to improve
M.V. Sprindzuk, V.I. Bernik, A.P. Konchits   +2 more
doaj   +1 more source

MOMA: a multi-task attention learning algorithm for multi-omics data interpretation and classification. [PDF]

Bioinformatics, 2022
Moon S, Lee H.
europepmc   +1 more source