Results 201 to 210 of about 2,428,909 (308)

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Are standardized conditions needed for correct CGM data interpretation in subjects at early stages of glucose intolerance? [PDF]

Diabetol Metab Syndr
Dimova R, Chakarova N, Tankova T.
europepmc   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

How to take action beyond ambulatory glucose profile: Latin American expert recommendations on CGM data interpretation. [PDF]

Diabetol Metab Syndr
Calliari LE, Contreras Sepúlveda Á, Coronel-Restrepo N, Kabakian L, Lamounier RN, Picasso E, Proietti A, Ramírez-Rincón A, Yépez-Rodriguez AE.   +8 more
europepmc   +1 more source

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

FEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source

The hidden impact of in-source fragmentation in metabolic and chemical mass spectrometry data interpretation. [PDF]

Nat Metab
Giera M, Aisporna A, Uritboonthai W, Siuzdak G.   +3 more
europepmc   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Assessment of salivary microRNA by RT-qPCR: Facing challenges in data interpretation for clinical diagnosis. [PDF]

PLoS One
Van Der Hofstadt M, Cardinal A, Lepeltier M, Boulestreau J, Ouedraogo A, Kahli M, Champigneux P, Molina L, Molina F, Van TNN.   +9 more
europepmc   +1 more source

Investigator triangulation in the data interpretation process. An almost untouched research area

, 2017
Anne Schippling
openalex   +1 more source

Processing and interpretation of advanced space-borne thermal emission and reflection radiometer (ASTER) data for lithological mapping in ophiolite complex

, 2011
Mazlan Hashim
openalex   +1 more source