Results 41 to 50 of about 121,119 (257)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Decolonial Data Law and Governance

Technology and Regulation
In the introduction to this special issue, we propose a decolonial take on data law and governance across three aspects through the dismantling of hegemonic structures, the embracing of pluriversality and finally the decentering of data and ...
Siddharth Peter de Souza, Hellen Mukiri Smith, Linnet Taylor   +2 more
doaj   +1 more source

Forensic comparison of fired cartridge cases: Feature-extraction methods for feature-based calculation of likelihood ratios

Forensic Science International: Synergy, 2022
We describe and validate a feature-based system for calculation of likelihood ratios from 3D digital images of fired cartridge cases. The system includes a database of 3D digital images of the bases of 10 cartridges fired per firearm from approximately ...
Nabanita Basu, Rachel S. Bolton-King, Geoffrey Stewart Morrison   +2 more
doaj   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Civil society and the (im)possibilities of algorithmic contestation in migration governance

Frontiers in Sociology
The present article examines the (im)possibilities of contesting algorithmic systems in migration governance through an empirical study of civil society organizations in Sweden and Norway.
Stoyanka Andreeva Eneva, Fredy Mora-Gámez, Fredy Mora-Gámez   +2 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Lutter contre les violences des données issues de la datafication

Communication
As a result of certain datafication practices, data essentialization causes queer people to suffer invisibility in their daily lives and discrimination due to poorly calibrated datasets and associated algorithms.
Ugo Verdi
doaj   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Big Data Discourses| Toward Disability Data Justice: A Critical Discussion of Disability and Big Data Discourses

International Journal of Communication
The terms of inclusion/exclusion of disability in big data are ultimately connected to the kinds of discourses that inform disability in society. Since the rise of big data as a phenomenon, disability’s absence in it, especially in the data formations ...
Kuansong Victor Zhuang, Gerard Goggin
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source