Results 191 to 200 of about 525,062 (261)

Optimizing data linkage for maximizing the potential of Luxembourg's national cancer registry: a comprehensive scoping review. [PDF]

Front Oncol
Lima B, Hasan F, Kannan P, Schnell M, Mafra A, Couffignal S, Backes C.   +6 more
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Single-Multiple and Recurrent Pregnancy-Related Complications and Incident Cardiovascular Disease: A Nationwide Data Linkage Study in Wales, UK. [PDF]

J Am Heart Assoc
Al Bahhawi T, Harrison SL, Lane DA, Skjøth F, Buchan I, Sharp A, Abbasizanjani H, Akbari A, Torabi F, Halcox J, Hapangama DK, Lip GYH.   +11 more
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Inter-pregnancy interval after caesarean section and subsequent pregnancy outcomes in New South Wales. A data linkage cohort protocol. [PDF]

MethodsX
Canty AM, Am AH, You W, Keedle H, Makris A.   +4 more
europepmc   +1 more source