Results 131 to 140 of about 10,184,633 (357)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Relation Discovery from Web Data for Competency Management [PDF]

, 2007
This paper describes a technique for automatically discovering associations between people and expertise from an analysis of very large data sources (including web pages, blogs and emails), using a family of algorithms that perform accurate named-entity ...
Eisenstadt, M., Goncalves, A, Motta, E., Pacheco, R, Song, D., Uren, V., Zhu, J.L.   +6 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Application level microcode to speed data base management [PDF]

, 1979
P. A. Dearnley
openalex   +1 more source

Grid Data Management in Action: Experience in Running and Supporting Data Management Services in the EU DataGrid Project

, 2003
In the first phase of the EU DataGrid (EDG) project, a Data Management System has been implemented and provided for deployment. The components of the current EDG Testbed are: a prototype of a Replica Manager Service built around the basic services ...
Andronico, Giuseppe, Donno, Flavia, Kunszt, Peter, Laure, Erwin, Millar, Paul, Muzaffar, Shahzad, Stockinger, Heinz   +6 more
core  

Adaptive Data Stream Management System Using Learning Automata

, 2011
In many modern applications, data are received as infinite, rapid, unpredictable and time- variant data elements that are known as data streams. Systems which are able to process data streams with such properties are called Data Stream Management Systems
Abdi, Fatemeh, Haghjoo, Mostafa S., Mohammadi, Shirin, Safaei, Ali A.   +3 more
core   +2 more sources

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Self-organising data management systems [PDF]

, 1973
Peter Stocker
openalex   +1 more source

Data management and analysis with WRF and SFIRE

, 2012
We introduce several useful utilities in development for the creation and analysis of real wildland fire simulations using WRF and SFIRE. These utilities exist as standalone programs and scripts as well as extensions to other well known software.
Beezley, Jonathan, Kochanski, Adam K., Mandel, Jan, Martin, Mavin, Rosen, Paul   +4 more
core   +1 more source

Characterizing epithelial‐mesenchymal transition‐linked heterogeneity in breast cancer circulating tumor cells at a single‐cell level

Molecular Oncology, EarlyView.
In over 50% of non‐metastatic breast cancer patients, circulating tumor cells (CTCs) along the whole epithelial‐mesenchymal transition spectrum are detected. Total CTC number and individual phenotypes relate to aggressive disease characteristics, including lymph node involvement and higher tumor proliferation. At the single‐cell level, mesenchymal CTCs
Justyna Topa, Julia Richert, Tomasz Stokowy, Alicja Staśczak, Mariusz Szajewski, Maciej Ciesielski, Petra M. Grešner, Bartłomiej Tomasik, Łukasz Arcimowicz, Agnieszka Stankiewicz, Grażyna Suchodolska, Elżbieta Senkus, Wiesław Kruszewski, Anna J. Żaczek, Aleksandra Markiewicz   +14 more
wiley   +1 more source