Results 91 to 100 of about 1,032,590 (316)
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
, 2022 Atualmente existem empresas que possuem informação bastante valiosa, sendo necessário que haja uma boa gestão dos seus dados. Os sistemas de armazenamento têm um ciclo de vida, o que faz com que seja necessária a sua atualização periódica. Sendo assim, o processo de migração tornou-se fulcral para a atualização dos repositórios das empresas.
openaire +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Tongxin xuebaoFocused on the problem that the stream computing platform was suffering from the high energy consumption and low efficiency due to the lack of consideration for energy efficiency in designing process, an energy-efficient optimization strategy based on ...
Yonglin PU +4 more
doaj
Eos, Transactions American Geophysical Union, 1989 Migration is one of those subjects that is difficult to explain to nonbelievers. The goal of migration is to generate an image of the subsurface velocity structure, but in order to migrate, one must first assume a velocity structure. Furthermore, until recently, nobody knew the meaning of the numbers output from migration; they were just numbers that ...
openaire +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Least Squares Reverse Time Migration of Ground Penetrating Radar Data Based on Modified Total Variation [PDF]
, 2023 Qianwei Dai, Shaoqing Wang, Yi Lei
openalex +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Seismic reflection imaging of deep crustal structures via reverse time migration using offshore wide-angle seismic data on the eastern margin of the Sea of Japan [PDF]
, 2022 Kazuya Shiraishi, Tetsuo No, Gou Fujie
openalex +1 more source
Molecular Oncology, EarlyView.To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source