Results 31 to 40 of about 1,032,590 (316)

Clinical trial master file migration: A preordained step for a centralized electronic trial master file

Perspectives in Clinical Research, 2020
The need to speed up clinical trial processes in a cost-effective manner, increased importance of data integrity, and ensuring timely compliance to regulatory requirement updates regarding the Trial Master File (TMF), has made the pharmaceutical industry
Zainab Mehboob Rupani
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

The magnitude of climate change-induced migration: an overview of projections and a case for attribution

Frontiers in Climate
Many studies now provide evidence of weather and climate effects on human migration, but only few have attempted to project the impact of future climate change, or attribute the impact of past climate change, on global migration patterns. Here we compare
Jacob Schewe, Robert Beyer
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Modeling climate migration: dead ends and new avenues

Frontiers in Climate, 2023
Understanding and forecasting human mobility in response to climatic and environmental changes has become a subject of substantial political, societal, and academic interest.
Robert M. Beyer, Jacob Schewe, Guy J. Abel, Guy J. Abel   +3 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Is being a 'left-behind' child associated with an increased risk of self-poisoning in adulthood? Findings from a case–control study in Sri Lanka

BMJ Global Health, 2021
Purpose The long-term consequences of parental emigration on offspring self-harm risk is unknown.Methods We investigated the association between experiencing parental emigration in childhood with hospital presentations for self-poisoning in adulthood ...
David Gunnell, Paul Moran, Laura D Howe, Duleeka Knipe, Piumee Bandara, Thilini Rajapakse, Kolitha Wickramage   +6 more
doaj   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Physical Activity in Relation to Wellbeing Among Newly Arrived Refugees in Sweden: A Quantitative Study

Frontiers in Public Health, 2021
Background: Little is known about physical activity among newly arrived refugees and what impact physical activity might have on their health, as measured by mental wellbeing, vitality, stress and sleep quality. Thus, this study sought to investigate the
Katarina Sjögren Forss, Elisabeth Mangrio, Elisabeth Mangrio, Matti Leijon, Mathias Grahn, Slobodan Zdravkovic, Slobodan Zdravkovic   +6 more
doaj   +1 more source

Model-Driven Data Migration

, 2010
The automatic generation of components from abstract models greatly facilitates information systems evolution, as changes to the model are easier to comprehend than changes to program code or service definitions. At each evolutionary step, however, any data already held in the system must be migrated to the new version, and to do this manually can be ...
Aboulsamh, M, Crichton, E, Davies, J, Welch, J   +3 more
openaire   +2 more sources