Results 91 to 100 of about 42,084,791 (333)
CPT: Pharmacometrics & Systems PharmacologyA joint modeling framework was developed using data from 75 patients of early amcenestrant phase I–II AMEERA‐1‐2 dose escalation and expansion cohorts. A semi‐mechanistic tumor growth inhibition (TGI) model was developed.
Marc Cerou +7 more
doaj +1 more source
Nonlinear Panel Data Models [PDF]
, 2008 Panel or longitudinal data are becoming increasingly popular in applied work as they offer a number of advantages over pure cross-sectional or pure time-series data. A particularly useful feature is that they allow researchers to model unobserved heterogeneity at the level of the observational unit, where the latter may be an individual, a household, a
openaire +1 more source
FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
Regression modeling on stratified data with the lasso
, 2016 We consider the estimation of regression models on strata defined using a categorical covariate, in order to identify interactions between this categorical covariate and the other predictors.
Ollier, Edouard, Viallon, Vivian
core +3 more sources
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
AxiomsThis paper establishes two novel recurrence relations for Stirling numbers of the second kind—an L recurrence and a vertical recurrence—discovered through a probabilistic analysis of Poisson higher-order origin moments.
Ying-Ying Zhang, Dong-Dong Pan
doaj +1 more source
A Practically Competitive and Provably Consistent Algorithm for Uplift Modeling
, 2017 Randomized experiments have been critical tools of decision making for decades. However, subjects can show significant heterogeneity in response to treatments in many important applications.
Fang, Xiao +2 more
core +1 more source
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Modeling Blank Data Entries in Data Envelopment Analysis [PDF]
We show how Data Envelopment Analysis (DEA) can handle missing data. When blank data entries are coded by appropriate dummy values, the DEA model automatically excludes the missing data from the analysis.
Timo Kuosmanen
core
An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots
FEBS Letters, EarlyView.This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino +7 more
wiley +1 more source