Results 101 to 110 of about 42,084,791 (333)

Variational Bayesian Variable Selection for High-Dimensional Hidden Markov Models

Mathematics
The Hidden Markov Model (HMM) is a crucial probabilistic modeling technique for sequence data processing and statistical learning that has been extensively utilized in various engineering applications.
Yao Zhai, Wei Liu, Yunzhi Jin, Yanqing Zhang   +3 more
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Autonomous Normal–Cancer Discrimination by a LATS/pLATS-Explicit Hippo–YAP/TAZ Reaction System

Mathematics
In this study, we propose a minimal reaction system for the Hippo–YAP/TAZ pathway that explicitly includes inactive LATS, active pLATS, cytoplasmic and nuclear YAP/TAZ, and phosphorylated YAP/TAZ.
Toshihito Umegaki, Takashi Suzuki
doaj   +1 more source

An Examination of the Agreement between Self-reported Diabetes and Paraclinical Tests, Medical Records, and Clinical Examinations: Insights from the Shahedieh Cohort Study, Yazd, Iran [PDF]

Journal of Caring Sciences
Introduction: Many researchers utilize self-reports to evaluate the prevalence of diseases. However, the accuracy of these self-reports remains uncertain in various studies.
Farzan Madadizadeh, Mahdieh Momayyezi, Hossein Fallahzadeh   +2 more
doaj   +1 more source

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

Location Dependent Dirichlet Processes

, 2017
Dirichlet processes (DP) are widely applied in Bayesian nonparametric modeling. However, in their basic form they do not directly integrate dependency information among data arising from space and time.
A Oliva, A Rodríguez, C Bishop, C Williams, CE Rasmussen, D Blei, D Blei, D Dunson, E Sudderth, F Zhu, H Ishwaran, J Duan, J Griffin, J Griffin, J Paisley, J Sethuraman, J Shi, L Ren, N Foti, P Orbanz, R Unnikrishnan, S Kumar, T Ferguson, X Sun, YW Teh   +24 more
core   +1 more source

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Shape optimization problem based on the generalized J integral considering RANS and Snapshot POD

Journal of Fluid Science and Technology, 2019
For suppression of time periodic flow and normal stress using optimal design techniques, this paper presents an optimal shape by sensitivity based on the Generalized J Integral, and makes a comparison to results of sensitivity evaluated by boundary and ...
Takashi NAKAZAWA
doaj   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source