Results 161 to 170 of about 27,515,411 (316)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Data modeling the interplay between single-cell shape, single-cell protein expression, and tissue state. [PDF]

Cell Rep Methods
Tamir Y, Bussi Y, Owczarek C, Luque L, Torrisi G, Rose LA, Kliper-Gross O, Schumacher L, Parsons M, Keren L, Zaritsky A.   +10 more
europepmc   +2 more sources

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Predicting asthma using imbalanced data modeling techniques: Evidence from 2019 Michigan BRFSS data. [PDF]

PLoS One, 2023
Budhathoki N, Bhandari R, Bashyal S, Lee C.   +3 more
europepmc   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Supporting data for the paper Permeability Predictions in the Hydrate-bearing Sediments Using Pore Network Modeling

This gives all the supporting data for the paper "Permeability Predictions in the Hydrate-bearing Sediments Using Pore Network Modeling".THIS DATASET IS ARCHIVED AT DANS/EASY, BUT NOT ACCESSIBLE HERE.
Zhang, Y (via Mendeley Data), Zhang, Yongchao   +1 more
core   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Association between Serum Liver Enzymes and Hypertension: Findings from Shahedieh Yazd Cohort Study, Iran [PDF]

Journal of Community Health Research
Background: Hypertension, known as a silent killer, leads to various complications and may influence serum liver enzymes, potentially resulting in liver diseases.
Kousar Zardosht, Zahra Mandegari, Sara Jambarsang, Moslem Taheri Soodejani, Seyyed Mohammad Tabatabaei, Hossein Akhondi   +5 more
doaj  

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

An effective correlation-based data modeling framework for automatic diabetes prediction using machine and deep learning techniques. [PDF]

BMC Bioinformatics, 2023
Patro KK, Allam JP, Sanapala U, Marpu CK, Samee NA, Alabdulhafith M, Plawiak P.   +6 more
europepmc   +1 more source