Results 101 to 110 of about 2,612,468 (303)

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

A convolutional neural network with image and numerical data to improve farming of edible crickets as a source of food—A decision support system

Frontiers in Artificial Intelligence
Crickets (Gryllus bimaculatus) produce sounds as a natural means to communicate and convey various behaviors and activities, including mating, feeding, aggression, distress, and more. These vocalizations are intricately linked to prevailing environmental
Henry Kyalo, Henry Kyalo, Henri E. Z. Tonnang, Henri E. Z. Tonnang, James P. Egonyu, John Olukuru, Chrysantus M. Tanga, Kennedy Senagi   +7 more
doaj   +1 more source

Modelling and Parameter Identification Using Reduced I-V Data [PDF]

, 2017
No abstract ...
Lim, Li Hong Idris, Tay, Shaun, Ye, Zhen
core  

Remarkable properties for diagnostics and inference of ranking data modelling. [PDF]

Br J Math Stat Psychol, 2022
Mollica C, Tardella L.
europepmc   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Accelerating antibody development: sequence and structure-based models for predicting developability properties via size exclusion chromatography

mAbs
Experimental screening for biopharmaceutical developability properties typically relies on resource-intensive, and time-consuming assays such as size exclusion chromatography (SEC).
A N M Nafiz Abeer, Mehdi Boroumand, Isabelle Sermadiras, Jenna G. Caldwell, Valentin Stanev, Neil Mody, Gilad Kaplan, James Savery, Rebecca Croasdale-Wood, Maryam Pouryahya   +9 more
doaj   +1 more source

Data modelling of subsistence retail consumer purchase behavior in South Africa. [PDF]

Data Brief, 2022
Zulu VM, Nkuna AM.
europepmc   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

A digital twin framework for urban parking management and mobility forecasting

Nature Communications
Rapid urbanization and population growth have created significant challenges in urban mobility management, such as traffic congestion, inefficient public transportation, and environmental pollution. Here we present the development and implementation of a
Francesco Piccialli, Sara Amitrano, Donato Cerciello, Anna Borrelli, Edoardo Prezioso, Marzia Canzaniello   +5 more
doaj   +1 more source