Results 121 to 130 of about 2,612,468 (303)
Computer Methods in Biomechanics and Biomedical Engineering: Imaging & VisualizationBreast cancer remains a leading cause of mortality and requires early and accurate diagnosis to improve patient outcomes. Traditional diagnostic methods often rely on either clinical records or imaging, limiting their ability to capture complementary ...
Tayfun Kok, Temitayo Matthew Fagbola
doaj +1 more source
Unlocking Potential within Health Systems Using Privacy-Preserving Record Linkage: Exploring Chronic Kidney Disease Outcomes through Linked Data Modelling. [PDF]
Appl Clin Inform, 2022 Lim D +11 more
europepmc +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Flexible modelling in statistics: past, present and future [PDF]
, 2014 In times where more and more data become available and where the data exhibit rather complex structures (significant departure from symmetry, heavy or light tails), flexible modelling has become an essential task for statisticians as well as researchers ...
Ley, Christophe
core +2 more sources
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
A Survey on Distributed Fibre Optic Sensor Data Modelling Techniques and Machine Learning Algorithms for Multiphase Fluid Flow Estimation. [PDF]
Sensors (Basel), 2021 Arief HA, Wiktorski T, Thomas PJ.
europepmc +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Massive non-thermal radio emitters: new data and their modelling
, 2011 During recent years some non-thermal radio emitting OB stars have been discovered to be binary, or multiple systems. The non-thermal emission is due to synchrotron radiation that is emitted by electrons accelerated up to high energies.
Blomme, R. +3 more
core
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source