Results 131 to 140 of about 2,612,468 (303)

ICONQUER: A Transformer-Based Instruction-Finetuned Context-Aware Medical Question Answering Model With Knowledge Graph Augmentation

IEEE Access
Medical Question Answering (MQA) systems are vital for clinical decision support, yet most existing models struggle with complex query processing, fine-grained context awareness, and explainability. This study introduces ICONQUER, a transformer-based MQA
Samuel Mbah, Temitayo Matthew Fagbola, Bhupesh Kumar Mishra, Tareq Al Jaber, Surendra Colin Thakur, Turke Althobaiti   +5 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Orbital learning: a novel, actively orchestrated decentralised learning for healthcare

Scientific Reports
A novel collaborative and continual learning across a network of decentralised healthcare units, avoiding identifiable data-sharing capacity, is proposed. Currently available methodologies, such as federated learning and swarm learning, have demonstrated
Neeraj Kavan Chakshu, Perumal Nithiarasu
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Modelling the reporting discrepancies in bilateral data [PDF]

This paper is about the discrepancies in reported bilateral statistical data ("mirror data"). For example the trade from country A to country B is not reported the same in the two countries.
Arie ten Cate
core  

Data modelling consumer-generated content usage for apparel shopping. [PDF]

Data Brief, 2020
Tobias-Mamina RJ, Kempen E.
europepmc   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

In Silico Simulation of Porous Geometry-Guided Diffusion for Drug-Coated Tissue Engineering Scaffold Design

Organoids
Recent research works have shown the effect of nutrient concentration on cell activity, such as proliferation and differentiation. In 3D cell culture, the impact of scaffold geometry, including pore size, strut diameter, and pore shape, on the ...
Eyad Awad, Matthew Bedding-Tyrrell, Alberto Coccarelli, Feihu Zhao   +3 more
doaj   +1 more source

Modelling and refinement of forensic data acquisition specifications [PDF]

, 2014
Aziz, Benjamin
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source