Results 231 to 240 of about 32,466,082 (318)

National COVID Cohort Collaborative data enhancements: a path for expanding common data models. [PDF]

J Am Med Inform Assoc
Walters KM, Clark M, Dard S, Hong SS, Kelly E, Kostka K, Lee AM, Miller RT, Morris M, Palchuk MB, Pfaff ER, N3C and RECOVER Consortia.   +11 more
europepmc   +1 more source

Models, data models, and big data

Leticia Castillo Brache, Alisa Bokulich
openaire   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Matrix Completion When Missing Is Not at Random and Its Applications in Causal Panel Data Models. [PDF]

J Am Stat Assoc
Choi J, Yuan M.
europepmc   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

A rapid review on the application of common data models in healthcare: Recommendations for data governance and federated learning in artificial intelligence development. [PDF]

Digit Health
von Gerich H, Chomutare T, Kytö V, Lundberg P, Siggaard T, Peltonen LM.   +5 more
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Common data models to streamline metabolomics processing and annotation, and implementation in a Python pipeline. [PDF]

PLoS Comput Biol
Mitchell JM, Chi Y, Thapa M, Pang Z, Xia J, Li S.   +5 more
europepmc   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Europe's Largest Research Infrastructure for Curated Medical Data Models with Semantic Annotations. [PDF]

Methods Inf Med
Riepenhausen S, Blumenstock M, Niklas C, Hegselmann S, Neuhaus P, Meidt A, Püttmann C, Storck M, Ganzinger M, Varghese J, Dugas M.   +10 more
europepmc   +1 more source