Results 111 to 120 of about 24,886,306 (283)

The Plane Quasar Survey: First Data Release

The Astrophysical Journal Supplement Series
We present a sample of 305 QSO candidates having ∣ b ∣ < 30°, the majority with GALEX magnitudes near-UV < 18.75. To generate this sample, we apply UV–IR color selection criteria to photometric data from the Ultraviolet Galactic Plane Survey as part of ...
Jessica Werk, Kirill Tchernyshyov, Hannah Bish, Yong Zheng, Mary Putman, Joshua Peek, David Schiminovich   +6 more
doaj   +1 more source

A Collaborative Data-Plane and Control-Plane Architecture for Real-Time Anomaly Detection

IEEE Access
Programmable data planes enable real-time traffic monitoring and line-rate response. However, their limited computational capabilities restrict deep packet inspection.
Xiao Tian, Jinjiang Liu, Qinglei Qi, He Li, Xiaopu Ma, Cong Zhao   +5 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Semilinear equations in the plane with measurable data

Доповiдi Нацiональної академiї наук України
We study semilinear partial differential equations in the plane, the linear part of which is written in a divergence form. The main result is given as a factorization theorem.
V.Ya. Gutlyanskiĭ, O.V. Nesmelova, V.I. Ryazanov   +2 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Sketch-based data plane hardware model for software-defined measurement

Tongxin xuebao, 2017
A sketch-based data plane hardware model for software-defined measurement was introduced,and it was implemented in the programmable network device NetMagic.A generic sketch model for collecting flow-level data using high-speed memories on the FPGA was ...
Mian DAI, Guang CHENG
doaj   +2 more sources