Results 111 to 120 of about 2,559,985 (286)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Performance optimization solutions for NFV data plane

open access: yesDianxin kexue, 2017
In recent years,network function virtualization (NFV) is arousing concern widely from both academia and industry due to its flexible deployment and low cost.However,the performance bottleneck becomes increasingly distinctive and hinders the progress of ...
Yukai HUANG   +3 more
doaj   +2 more sources

Network Data Plane Programming Languages: A Survey

open access: yesComputers
Network data plane programming is a consequence of the evolution of the concept of control and data plane separation, stated two decades ago, and established on the Software-Defined Networking (SDN) architecture.
Belén Brandino, Eduardo Grampín
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Open Data Plane Development Kit (DPDK) Encapsulation Data-Plane

open access: yes, 2016
El proyecto explora el despliegue en un entorno real de una aplicación que implementa un data-plane LISP basado en el framework Intel DPDK. Se han estudiado diferentes escenarios, optimizado las configuraciones y analizado el rendimiento del despliegue bajo diferentes cargas de tráfico.
openaire   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

The Plane Quasar Survey: First Data Release

open access: yesThe Astrophysical Journal Supplement Series
We present a sample of 305 QSO candidates having ∣ b ∣ < 30°, the majority with GALEX magnitudes near-UV < 18.75. To generate this sample, we apply UV–IR color selection criteria to photometric data from the Ultraviolet Galactic Plane Survey as part of ...
Jessica Werk   +6 more
doaj   +1 more source

A Collaborative Data-Plane and Control-Plane Architecture for Real-Time Anomaly Detection

open access: yesIEEE Access
Programmable data planes enable real-time traffic monitoring and line-rate response. However, their limited computational capabilities restrict deep packet inspection.
Xiao Tian   +5 more
doaj   +1 more source

Home - About - Disclaimer - Privacy