Results 81 to 90 of about 2,002,690 (314)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

SliceNet programmable data plane control in 5G network slicing [PDF]

, 2019
Network slicing has become a major networking paradigm in 5G networks to meet the diverse Quality of Ser- vice (QoS) requirements from different use cases.
Navid, Nikaein, Salva-Garcia, Pablo; id_orcid, Iordache, Marius, Koutsopoulos, Konstantinos, Bernini, Giacomo, Patachia, Cristian, Alcaraz-Calero, Jose M., Baldini, Luca, Figueiredo, Ricardo, Chirivella-Perez, Enrique, Wang, Qi; id_orcid, Maione, Biagio, Borlizzi, Giacomo, Angelo, Ciriaco   +13 more
core   +1 more source

Towards extreme network KPIs with programmability in 6G

, 2023
<p>6G's superpower must be simplicity, which should not be viewed as a constraint, but rather as the organic outcome of using the most advanced technologies at our disposal.
Pongrácz, Gergely, Nanos, Anastassios, Mihály, Atilla, Gódor, István, Laki, Sandor, Papagianni, Chrysa   +5 more
core   +2 more sources

Traffic Engineering in Software Defined Networks: A Survey

Journal of Telecommunications and Information Technology, 2016
An important technique to optimize a network and improve network robustness is traffic engineering. As traffic demand increases, traffic engineering can reduce service degradation and failure in the network. To allow a network to adapt to changes in the
Mohammad Reza Abbasi, Ajay Guleria, Mandalika S. Devi   +2 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Energy-Aware Routing in Multiple Domains Software-Defined Networks

Advances in Distributed Computing and Artificial Intelligence Journal, 2016
The growing energy consumption of communication networks has attracted the attention of the networking researchers in the last decade. In this context, the new architecture of Software-Defined Networks (SDN) allows a flexible programmability, suitable ...
Adriana FERNÁNDEZ-FERNÁNDEZ, Cristina CERVELLÓ-PASTOR, Leonardo OCHOA-ADAY   +2 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source