Results 91 to 100 of about 6,413 (266)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Aswameda Sebagai Prosesi Ritual Berbalut Kuasa dalam Teks Aswamedaparwa

open access: yesHumanis
Research about Aswameda as a ritual procession wrapped in power in the text Aswamedaparwa this aims to expand social life in literary works related to power.
I Nyoman Duana Sutika   +1 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

The e-text corpus RusNeuroPsych: composition, structure and applicability

open access: yesStudia Humanitatis, 2016
The article describes the text corpus RusNeuroPsych developed in the Russian language. It contains the meta-marking as information about the authors (gender, age, education, results of neuropsychological survey and psychological testing). We consider the
Litvinova Tatiana Aleksandrovna   +1 more
doaj  

Processing of Qualitative Data

open access: yes, 2016
To overcome some problems with deep understanding of fuzzy values, certain learning finite automaton was put into a fuzzy environment. Previously such a device has been studied in the probabilistic environment, where the classic technique of standard Markov chains was applicable.
openaire   +3 more sources

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

THE IMPORTANCE OF PROTECTION OF AUTOCHTHONOUS DAIRY PRODUCTS AND POSSIBILITIES TO INCREASE AUTOCHTHONOUS DAIRY PRODUCTS PRODUCTION OBSERVED AS FACTORS IN THE DEVELOPMENT OF THE MUNICIPALITY OF ŠTRPCE

open access: yesEkonomika Poljoprivrede (1979), 2018
Security situation in Kosovo and Metohija and traffic circumstances – in other words - distance between the municipality of Štrpce and bigger consumer centres in Serbia and other factors restrict milk procession in the existing diary plant and on ...
Slavica Arsić   +2 more
doaj  

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