Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Zhishi guanli luntan, 2019 [Purpose/significance] Scientific data publishing is the main mode of academic communication for data-intensive scientific discovery, which is of great significance for data reuse and scientific verification.
Han Lu, Ding Yi
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Experiments and Analyses of Anonymization Mechanisms for Trajectory Data Publishing. [PDF]
J Comput Sci Technol, 2022 Sun S +5 more
europepmc +1 more source
Origins of Modern Data Analysis Linked to the Beginnings and Early Development of Computer Science and Information Engineering [PDF]
, 2008 The history of data analysis that is addressed here is underpinned by two themes, -- those of tabular data analysis, and the analysis of collected heterogeneous data.
Murtagh, Fionn
core +2 more sources
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Differential privacy medical data publishing method based on attribute correlation. [PDF]
Sci Rep, 2022 Zhang S, Li X.
europepmc +1 more source
Highlights from the SOAP project survey. What Scientists Think about Open Access Publishing
, 2011 The SOAP (Study of Open Access Publishing) project has run a large-scale survey of the attitudes of researchers on, and the experiences with, open access publishing.
Dallmeier-Tiessen, Suenje +16 more
core
A Fully Parameterized Fem Model for Electromagnetic Optimization of an RF Mems Wafer Level Package [PDF]
, 2007 In this work, we present a fully parameterized capped transmission line model for electromagnetic optimization of a wafer level package (WLP) for RF MEMS applications using the Ansoft HFSS-TM electromagnetic simulator.
Bartek, M. +4 more
core +2 more sources
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source