Results 181 to 190 of about 5,645,319 (318)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Analyzing Data Quality Investments in CRM - A Model-based Approach

, 2003
Known as Customer Relationship Management (CRM) in recent years a concept for business that focuses customers is often discussed in research and practice. After initially extraordinary expectations, numerous CRM projects fail. Thereby as one of the major
Heinrich, Bernd, Helfert, Markus
core  

A Practical Approach to Assessing the Completeness of Electronic Health Records for Medical Research: Data Quality Study. [PDF]

JMIR Med Inform
Lim M, An D, Son N, Sunwoo W, Lee S.
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

[Data--quality--quality of data].

Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1995
O F, Sellevold, S, Fasting
openaire   +1 more source

In Situ Growth of Metallic 1T-MoS2 on TiO2 Nanotubes with Improved Photocatalytic Performance

ACS Omega, 2021
Miaogen Chen, Tao Sun, Wan Zhao, Xiuru Yang, Wenya Chang, Xiaoxiao Qian, Qian Yang, Zhi Chen   +7 more
doaj   +1 more source

Assessing data quality of inflammatory bowel disease patients in the <i>All of Us</i> research program. [PDF]

JAMIA Open
Spotnitz M, Faye AS, Giannini J, Litwin TR, Ostchega Y, Berman L.   +5 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Anomaly Detection for Automated Data Quality Monitoring in the CMS Detector. [PDF]

EPJ Res Infrastruct
Brinkerhoff A, Sutantawibul C, Suarez I, White R, Daumann C, Guiang J, Freer C, May S, Marsh B, Acosta D, Aubuchon A, Barberis E, Bundock A, Campagnari C, Collins E, Epps P, Erdmann J, Flaecher H, Huang J, Nguyen V, Nie R, Paramesvaran S, Rotter J, Salyer K, Sawant S, Sheokand T, Wood D, the CMS Muon Detector Collaboration.   +27 more
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source