Results 241 to 250 of about 5,645,319 (318)

Towards reliable use of artificial intelligence to classify otitis media using otoscopic images: Addressing bias and improving data quality. [PDF]

PLoS One
Xu Y, Habib AR, Crossland G, Patel H, Perry C, Bock K, Lian T, Weeks WB, Dodhia R, Ferres JL, Singh NP.   +10 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Towards Spectral Variation Analysis: A Data Quality Framework for Non-Targeted Methods. [PDF]

Molecules
Nichani K, Uhlig S, San Martin V, Colson B, Hettwer K, Steinacker U, Kaspar H, Gowik P, Kemmlein S.   +8 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Towards a minimum reporting standard to promote animal welfare and data quality in biologging research. [PDF]

Anim Biotelemetry
Payne AR, Hale CM, Davidson SC, Kendall-Bar JM, Beltran RS.   +4 more
europepmc   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Digitizing rehabilitation outcomes and assessing data quality in clinical trials: implementing validated scales in REDCap for a stroke RCT. [PDF]

BMC Med Res Methodol
Nicora G, Sacchi L, Tibollo V, Cigliutti E, Caretti M, Falchini F, Mauro MC, Fasano A, Siotto M, Pavan A, Cortellini L, Lattanzi S, Bellazzi R, Aprile IG, Germanotta M, Quaglini S.   +15 more
europepmc   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Intensive, Repeated Self-Report Measures: Should We Be Concerned About Changes in Data Quality Over Time? [PDF]

JMIR Mhealth Uhealth
Stone AA, Schneider S, Toledo MJ, Hernandez R.   +3 more
europepmc   +1 more source