Results 271 to 280 of about 29,969,840 (342)

Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs

Molecular Oncology, EarlyView.
In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza, David James, Emma Creagh, James T. Murray   +3 more
wiley   +1 more source

Impact of Primary Health Care Data Quality on Infectious Disease Surveillance in Brazil: Case Study.

JMIR Public Health Surveill
Florentino PTV, Bertoldo Junior J, Barbosa GCG, Cerqueira-Silva T, Oliveira VA, Garcia MHO, Penna GO, Boaventura V, Ramos PIP, Barral-Netto M, Marcilio I.   +10 more
europepmc   +1 more source

Facing further challenges in cancer data quality and harmonisation. [PDF]

Front Oncol
Giusti F, Martos C, Carvalho RN, Zadnik V, Visser O, Bettio M, Van Eycken L.   +6 more
europepmc   +1 more source

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

Author Correction: Assessing citizen science data quality for bird monitoring in the Iberian Peninsula. [PDF]

Sci Rep
Prenda J, Domínguez-Olmedo JL, López-Lozano E, de Villarán RF, Negro JJ.   +4 more
europepmc   +1 more source

Pericytes change function depending on glioblastoma vicinity: emphasis on immune regulation

Molecular Oncology, EarlyView.
Pericytes alter their transcriptome depending on their proximity to the tumor core. In the tumor core, pericytes display a more active state with higher communication strength but with lower immune activation potential and a shift toward extracellular matrix production.
Carolina Buizza, Robert Carlsson, Coralie Gamper, Gayatri Chitale, Johan Bengzon, Gesine Paul   +5 more
wiley   +1 more source

Check your data before you wreck your model: The impact of careless responding on substance use data quality. [PDF]

Alcohol Clin Exp Res (Hoboken)
Braitman AL, Petrey AM, Shipley JL, Ayala Guzman R, Renzoni E, Looby A, Bravo AJ, Stimulant Norms and Prevalence 2 (SNAP2) Study Team.   +7 more
europepmc   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

A standardized image processing and data quality platform for rodent fMRI. [PDF]

Nat Commun
Desrosiers-Grégoire G, Devenyi GA, Grandjean J, Chakravarty MM.   +3 more
europepmc   +1 more source

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source